OUT-OF-HOSPITAL CARDIAC ARREST

This trial tests whether using two defibrillators in rapid succession, rather than one, can improve survival in people whose hearts stop outside a hospital. The procedure, called double sequential external defibrillation (DSED), is normally tried only after several failed attempt…

This study tests whether repeatedly inflating and deflating a blood pressure cuff on a leg can reduce brain damage in people who survive a cardiac arrest outside the hospital. The procedure, called remote ischemic post-conditioning (RIPOST), is started within 4 hours after the he…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This study tests whether emergency responders can safely use a special cooling vest on adults who have had a cardiac arrest and regained a pulse but remain unconscious. The vest is designed to cool the body quickly in the ambulance, which might protect the brain. The goal is to s…

This trial tests whether a new app and device can help community first responders give better CPR during out-of-hospital cardiac arrests. The enhanced system allows two-way audio and one-way video communication with dispatchers, plus real-time feedback on chest compressions. Rese…

This trial tests whether using two defibrillators in sequence, instead of the standard single defibrillator, can improve survival in people whose hearts are in a shockable rhythm but don't respond to the first shock. About 916 adults with out-of-hospital cardiac arrest will be ra…

This study tests whether using a heart-lung machine (ECMO) right at the scene of a cardiac arrest can improve survival and brain function. Researchers will compare how quickly ECMO can be started on-site versus in the hospital. The trial involves 100 adults who have a witnessed c…

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) during emergency treatment for out-of-hospital cardiac arrest can restart the heart and improve survival compared to the standard drug epinephrine alone. About 1,344 adults in T…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This study observes how core body temperature changes in adults who experience cardiac arrest outside the hospital. Researchers will measure temperature using a probe inserted into the esophagus during resuscitation and transport to the hospital. They will also track environmenta…

This study follows 30,000 people in Korea who experienced cardiac arrest outside a hospital, tracking their survival and brain function for up to six months. The goal is to understand the factors that influence outcomes, which could help improve emergency care and resuscitation p…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study tests whether a balloon device, called REBOA, can be safely used by emergency teams outside a hospital to improve blood flow in people whose heart has stopped (cardiac arrest). The balloon is inserted into the main artery and inflated to redirect blood to the heart and…

This study looks at rules doctors use to decide when to stop trying to revive someone after a cardiac arrest outside the hospital. These rules were made in Western countries, and this study checks if they work for people in Asia. Researchers will study 140,000 patients to see if …

This study explores using drones to quickly deliver automated external defibrillators (AEDs) to people helping someone having a cardiac arrest outside a hospital. Researchers will test the delivery process with training manikins and interview people with and without cardiac arres…

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside of a hospital. The goal is to better understand what happens before, during, and after the event, so doctors can improve care and survival rates. Participants are foll…

This study looks at how care in the emergency room (ER) after a heart attack affects short-term survival. Researchers will review records from 6,000 adults who had a heart attack outside the hospital and were revived in the ER. The goal is to find which ER treatments and timing h…

This study is testing a new training program that teaches doctors how to use a special ultrasound (TEE) during cardiac arrest. The program includes a lecture and hands-on practice with a simulator. Researchers are also developing an AI tool to assess how well doctors perform. The…

This study looks at 840 people in Paris whose hearts stopped and didn't restart with standard CPR. They received a special life-support machine called ECMO to keep blood flowing. Researchers will track how many survive for one year and how well their brains recover. The goal is t…