Will leg workouts save muscle while Weight-Loss drugs shed pounds?

NCT ID NCT07761923

Not yet recruiting Disease control Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study tests whether supervised leg exercises can preserve muscle mass in adults with obesity who are starting treatment with incretin-based weight-loss drugs. Participants will train one leg twice a week for 13 weeks, while the other leg serves as a comparison. Researchers will measure muscle volume, strength, and function to see if exercise helps maintain muscle during weight loss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Unilateral resistance training (supervised leg exercises)
What this could lead to: If effective, this approach could help people on weight-loss medications maintain muscle mass and physical function, improving overall health outcomes.
What could go wrong: The trial is small (20 participants) and short (13 weeks), so results may not apply broadly. Resistance training requires commitment and may not fully prevent muscle loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY (BMI > 35)

Contacts and locations

Locations

Karolinska Institutet

Stockholm, 17177, Sweden

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