Can weight-loss drugs and hormones make endometrial cancer surgery safer for obese women?
NCT ID NCT07462663
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assigned to either immediate surgery or the pre-surgery program. The goal is to see if the program reduces surgical risks without allowing the cancer to progress.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Semaglutide (weight-loss drug) and levonorgestrel IUD (hormonal device)
- What this could lead to
- If it works, this could point toward a safer, less invasive way to prepare for surgery in women with early endometrial cancer and severe obesity, potentially reducing surgical risks.
- What could go wrong
- This is a small pilot study (80 people) testing feasibility, not effectiveness. The pre-surgery delay could allow tumor progression, and the weight-loss drug may cause side effects like nausea or gastrointestinal issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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