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Double shock strategy for cardiac arrest put to the test in pilot trial

NCT ID NCT06447805

Completed Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether using two defibrillators early, instead of one, is feasible and safe for people whose hearts stop outside a hospital and don't respond to the first shock. Researchers enrolled 40 adults with a shockable heart rhythm. The goal was to see if emergency crews could follow the double-shock plan reliably and without harming patients. Results will help design a larger study to see if this approach saves more lives.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Double sequential defibrillation (using two defibrillators)
What this could lead to
If this approach proves feasible and safe, it could lead to a larger study that may improve survival for people whose heart rhythm doesn't respond to standard defibrillation.
What could go wrong
This is a small pilot study with only 40 participants, focused on feasibility, not on proving the treatment works. The results may not apply to all cardiac arrest patients, and there are risks like defibrillator malfunction or delays in CPR.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Death, Sudden, Cardiac sudden arrhythmia death syndrome sudden cardiac arrest ventricular fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST FIBRILLATION, VENTRICULAR SUDDEN CARDIAC ARREST SUDDEN CARDIAC DEATH

Contacts and locations

Locations

  • Emergency medical services Region Halland

    Halmstad, Halland County, 30238, Sweden

  • Sahlgrenska Universitetssjukhuset, Ambulans och Prehospital Akutsjukvård

    Gothenburg, Västra Götalandsregionen, 411 04, Sweden

  • Sjukhusen i väster, ambulanssjukvården Alingsås/Lerum

    Alingsås, Västra Götalandsregionen, 441 39, Sweden

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