SUDDEN CARDIAC DEATH

This study tests whether adding an implantable cardioverter defibrillator (ICD) to standard medication helps people with variant angina who have survived a sudden cardiac arrest. About 140 adults will be randomly assigned to get either an ICD plus medication or medication alone. …

This study compares a new pacing method (left bundle branch pacing) with a standard pacemaker-defibrillator in 30 people who have hypertrophic cardiomyopathy and a specific heart block after myectomy surgery. The goal is to see if the new method better prevents heart failure wors…

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery starts in the wrong place (AAOCA), which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and pr…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study compares two approaches for heart attack survivors with weak hearts: taking modern medications alone versus getting a defibrillator implant plus medications. The goal is to see if medication alone is as good at preventing sudden cardiac death. About 3,600 participants …

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand an…

This study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…

This study is looking for new genes and blood markers linked to arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can lead to heart failure and sudden cardiac arrest. Researchers will enroll 1,000 people, including patients with AVC or unexplained cardiac arrest…

This study looks at tiny particles called exosomes in the blood of 300 people who experienced sudden cardiac death after a heart attack. Researchers want to see if certain molecules in these particles can help predict who is at highest risk. The goal is to improve early warning a…

This study is observing 1,500 people with coronary artery disease to find better ways to predict who is at risk of sudden cardiac arrest. Researchers are looking at genetic, electrical, and biological markers, as well as psychological factors. The goal is to identify high-risk pa…

This study is testing whether advanced MRI and CT scans can identify people at highest risk for sudden cardiac death. Researchers will follow 400 participants who have low heart function and are scheduled to receive an implantable defibrillator. The goal is to see if these imagin…