SUDDEN CARDIAC DEATH

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal is…

This study tests a new pacing method (left bundle branch pacing) combined with a defibrillator in 30 people with hypertrophic cardiomyopathy who have already had heart surgery (myectomy). The goal is to see if this approach can prevent heart failure from getting worse, reduce dan…

This study aims to speed up and improve the diagnosis of a rare heart condition where a coronary artery grows from the wrong spot, which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and p…

This study tests whether people who have had a heart attack and have a weak heart can safely avoid getting a defibrillator implant if they take the latest heart medications. About 3,600 participants will be randomly assigned to receive either a defibrillator plus drugs or drugs a…

This study will enroll 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy or long QT syndrome. Researchers will collect DNA samples and medical information to find out which genes are most commonly affected in this population. The goal is to better und…

This study looks at tiny particles called exosomes in the blood of people who have had a sudden cardiac arrest. Researchers want to see if certain molecules in these particles can help predict who is at risk. The goal is to find better ways to identify high-risk patients early an…

This study watches how certain blood cancer drugs (BTK inhibitors or venetoclax) affect the heart's rhythm. About 135 adults with cancers like CLL or mantle cell lymphoma will have heart tests before and during treatment. The goal is to spot dangerous heart rhythms early and unde…

This study is testing a new artificial intelligence (AI) program called Willem that reads electrocardiograms (ECGs) — the test that records your heart's electrical activity. Researchers want to see if the AI can spot dangerous heart rhythms as well as a human heart specialist. Ov…

This study is observing 1,500 adults with coronary artery disease to identify which factors—like genetics, heart activity, or lifestyle—best predict sudden cardiac arrest or death. Researchers hope to find high-risk patients who could benefit from implantable defibrillators. The …

This study is looking for 1,000 people with a genetic heart condition called arrhythmogenic cardiomyopathy (AVC) or their family members. The goal is to discover new genes and blood markers that can predict who will get the disease, how it will progress, and who is at risk for da…

This study is testing whether new MRI and CT scans can better identify people at high risk for sudden cardiac death. Researchers will enroll 400 adults with weak hearts (ejection fraction 35% or less) who are scheduled to get an implantable defibrillator (ICD). The goal is to imp…