Heart risk from leukemia drugs under the microscope

NCT ID NCT05724121

Recruiting now Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 11 times

Summary

This study watches people with blood cancers like CLL who take BTK inhibitors or venetoclax to see how these drugs affect heart rhythm. Researchers will use EKGs, stress tests, and heart monitors to track abnormal rhythms and sudden death risk. The goal is to better understand and identify heart problems early in patients on these treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BTK inhibitors or venetoclax
What this could lead to: If successful, this study could help doctors better monitor and prevent heart rhythm problems in people taking BTK inhibitors for blood cancers.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly benefit participants. It may not find clear links or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac atrial fibrillation B-cell chronic lymphocytic leukemia cardiac rhythm disease Death, Sudden, Cardiac hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm mantle cell lymphoma sudden arrhythmia death syndrome sudden cardiac arrest Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARRHYTHMIAS CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) HEMATOLOGIC MALIGNANCIES MANTLE CELL LYMPHOMA SUDDEN CARDIAC DEATH WALDENSTR(SQRROOT)(DELTA)M S MACROGLOBULINEMIA

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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