Heart drug showdown: which Beta-Blocker best protects ICD patients?
NCT ID NCT06964464
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. Researchers will track which group has fewer heart-related hospitalizations, ICD shocks, or deaths over up to 3 years. The goal is to find out if one drug works better for this specific group of patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
carvedilol and metoprolol succinate (beta-blocker drugs)
What this could lead to
If it works, this could show which beta-blocker is better at preventing heart-related hospitalizations, ICD shocks, or death in heart failure patients with an ICD.
What could go wrong
This is a Phase 4 trial, so both drugs are already approved, but the study is open-label (not blinded), which may introduce bias. Results may not apply to all heart failure patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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AdventHealth Redmond
RECRUITINGRome, Georgia, 30165, United States
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AdventHealth Shawnee Mission
RECRUITINGShawnee Mission, Kansas, 66204, United States
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CHRISTUS Trinity Mother Frances Health System
RECRUITINGTyler, Texas, 75701, United States
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Creighton University Medical Center
RECRUITINGOmaha, Nebraska, 68124, United States
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Health University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Henry Ford Health System
RECRUITINGDetroit, Michigan, 48202, United States
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HonorHealth
RECRUITINGScottsdale, Arizona, 85258, United States
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New York-Presbyterian Brooklyn Methodist Hospital
RECRUITINGBrooklyn, New York, 11215, United States
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Suny Downstate
RECRUITINGBrooklyn, New York, 11203, United States
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University of Mossouri
RECRUITINGColumbia, Missouri, 65212, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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University of Wisconsin Hospital and Clinics
RECRUITINGMadison, Wisconsin, 53792, United States
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298, United States
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