Heart drug showdown: which Beta-Blocker best protects ICD patients?

NCT ID NCT06964464

Recruiting now Disease control Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. Researchers will track which group has fewer heart-related hospitalizations, ICD shocks, or deaths over up to 3 years. The goal is to find out if one drug works better for this specific group of patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: carvedilol and metoprolol succinate (beta-blocker drugs)
What this could lead to: If it works, this could show which beta-blocker is better at preventing heart-related hospitalizations, ICD shocks, or death in heart failure patients with an ICD.
What could go wrong: This is a Phase 4 trial, so both drugs are already approved, but the study is open-label (not blinded), which may introduce bias. Results may not apply to all heart failure patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arrhythmias, Cardiac cardiomyopathy Death, Sudden, Cardiac heart failure sudden arrhythmia death syndrome sudden cardiac arrest systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BETA-BLOCKER THERAPY CARDIOMYOPATHY HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF) IMPLANTABLE CARDIOVERTER DEFIBRILLATOR (ICD) SUDDEN CARDIAC DEATH VENTRICULAR ARRHYTHMIA

Contacts and locations

Locations

AdventHealth Redmond
RECRUITING

Rome, Georgia, 30165, United States
AdventHealth Shawnee Mission
RECRUITING

Shawnee Mission, Kansas, 66204, United States
CHRISTUS Trinity Mother Frances Health System
RECRUITING

Tyler, Texas, 75701, United States
Creighton University Medical Center
RECRUITING

Omaha, Nebraska, 68124, United States
Health University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
HonorHealth
RECRUITING

Scottsdale, Arizona, 85258, United States
New York-Presbyterian Brooklyn Methodist Hospital
RECRUITING

Brooklyn, New York, 11215, United States
Suny Downstate
RECRUITING

Brooklyn, New York, 11203, United States
University of Mossouri
RECRUITING

Columbia, Missouri, 65212, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Wisconsin Hospital and Clinics
RECRUITING

Madison, Wisconsin, 53792, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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