Leg strength may be key to heart health in rare condition

NCT ID NCT07420660

Completed Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This study looks at how leg muscle size and strength affect circulation in people born with a single-chamber heart, a condition where the heart can't pump blood to the lungs on its own. Researchers will measure muscle mass, oxygen use, and quality of life in 40 adults aged 16-50 who have had the Fontan procedure. The goal is to understand the link between muscles and circulation, which could lead to better exercise programs for these patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could lead to better exercise recommendations and muscle-strengthening programs to improve circulation and quality of life for people with single-chamber hearts.
What could go wrong: This is an observational study with only 40 participants, so results may not apply to everyone. It aims to understand the problem, not test a treatment, so direct benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital heart disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FONTAN CIRCULATION

Contacts and locations

Locations

Karolinska University Hospital

Stockholm, Sweden

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