Heart drug dosing study aims to protect fontan Patients' livers
NCT ID NCT06324396
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how liver congestion and scarring affect the way the body processes two common drugs, sildenafil and pravastatin, in people with Fontan circulation. Researchers will give a single dose of each drug to 15 participants aged 8 and older and measure drug levels in the blood. The goal is to improve dosing guidelines for this unique patient group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sildenafil and Pravastatin
What this could lead to
If successful, this could help doctors prescribe safer, more effective doses of common drugs for people with Fontan circulation.
What could go wrong
This is a very small, early-phase study with only 15 participants, so results may not apply to everyone. It only looks at drug levels, not long-term health outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Mercy Hospital
RECRUITINGKansas City, Missouri, 64108, United States
Contact
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