ISCHEMIC STROKE, ACUTE

This Phase 3 trial tests a drug called Fortelyzin® (non-immunogenic staphylokinase) in 990 adults with acute ischemic stroke who can be treated between 4.5 and 24 hours after symptoms begin. Participants receive a single injection of the drug or a placebo. The goal is to see if t…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in people who have had a stroke and undergone a clot removal procedure. Sixty participants will receive either real or sham TMS sessions alongside standard care. Researchers will m…

This study tests whether raising carbon dioxide levels slightly during general anesthesia can improve blood flow to the brain before clot removal in stroke patients. Fifty adults with large-vessel stroke will be randomly assigned to either normal or moderately high carbon dioxide…

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study looks at how a routine exercise program can help the brain rewire itself after a stroke. Researchers will measure changes in genes and proteins linked to brain repair in 48 stroke survivors with weakness on one side. The goal is to understand the biological effects of …