Could a breath of CO2 save Stroke-Damaged brain tissue?

NCT ID NCT05051397

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether raising carbon dioxide levels slightly during general anesthesia can improve blood flow to the brain before clot removal in stroke patients. Fifty adults with large-vessel stroke will be randomly assigned to either normal or moderately high carbon dioxide levels during the procedure. The goal is to see if this simple gas adjustment helps keep brain tissue alive until the clot is removed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

carbon dioxide

What this could lead to

If it works, this could point toward a simple way to protect the brain during stroke treatment by using carbon dioxide to boost blood flow.

What could go wrong

This is a small, early-phase trial with only 50 participants. The approach may not improve outcomes or could cause harm if carbon dioxide levels are not carefully managed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHU

    RECRUITING

    Clermont-Ferrand, 63000, France

    Contact

    Contact

    Contact Email: •••••@•••••

    Contact