Can a common antibiotic shield the brain after a stroke?

NCT ID NCT05487417

Completed Disease control Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial investigates whether the antibiotic minocycline can reduce brain injury in people with acute ischemic stroke who undergo mechanical thrombectomy (clot removal). Minocycline may protect the blood-brain barrier and limit damage from restored blood flow. The study enrolls adults aged 18–85 with large-vessel anterior circulation stroke and measures changes in infarct volume and functional recovery at three months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: the antibiotic minocycline
What this could lead to: If it works, minocycline could become a simple, widely available add-on treatment to reduce brain damage and improve outcomes after stroke thrombectomy.
What could go wrong: This is a mid-stage trial with 189 participants, so results may not apply to all stroke patients. Minocycline can cause side effects like dizziness, nausea, and antibiotic-related risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cerebral infarction cyclopia sequence ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIC STROKE, ACUTE

Contacts and locations

Locations

Xijing Hospital

Xi'an, China

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