Can a new Opioid-Like drug prevent dangerous blood pressure spikes during anesthesia?
NCT ID NCT07749131
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests an experimental drug called tegileridine to find the dose that best prevents sudden rises in blood pressure and heart rate when a breathing tube is placed during general anesthesia. The study includes adults aged 18 to 90 having elective surgery, with separate groups for younger and older patients. Researchers will adjust doses using a special sequential method to pinpoint the effective dose for 90% of people, aiming to make anesthesia safer, particularly for older adults.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tegileridine fumarate (SHR8554), an experimental opioid-like drug given intravenously before anesthesia induction to blunt the body's stress response to breathing tube placement.
- What this could lead to
- If successful, this could establish a precise dosing guide for tegileridine to make anesthesia induction safer, especially for older adults at higher cardiovascular risk.
- What could go wrong
- This is an early-phase dose-finding study, so the optimal dose may not be confirmed, and the drug could still cause side effects like sedation or breathing issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Shaoyang University Affiliated First Hospital
Shaoyang, Hunan, 422000, China
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