Could a simple drug order change emergency intubation success?
NCT ID NCT07741578
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial asks whether giving a muscle relaxant before a sedative, rather than the usual reverse order, improves the success of emergency intubation. It will involve 380 adults in the emergency department who need rapid sequence intubation. Researchers will compare first-pass success rates, time to intubation, oxygen levels, and risk of post-traumatic stress disorder between the two drug sequences.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- The order of two emergency drugs: a sedative (propofol) and a muscle relaxant (rocuronium), given during rapid sequence intubation.
- What this could lead to
- If one order works better, it could make emergency intubation safer and more successful, reducing complications like low oxygen levels and distress.
- What could go wrong
- This is a single-center trial, and results may not apply to all emergency settings. The order of drugs may not significantly change outcomes, and both drugs carry risks like low blood pressure or breathing problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RAPID SEQUENCE INDUCTION AND INTUBATION are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhongnan Hospital of Wuhan University
Wuhan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new Opioid-Like drug prevent dangerous blood pressure spikes during anesthesia?
- Which intubation tool works best? trial puts three devices Head-to-Head
- New Tube-Guiding technique may speed up stomach surgery prep
- Pain under anesthesia: study monitors hidden distress during emergency intubation
- Massive study aims to make emergency intubations safer
- Major study to test if video laryngoscopes improve First-Attempt success in Kids' intubation