New stroke drug TAK-755 enters human trials – could improve recovery

NCT ID NCT07392450

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This phase 2 trial is testing whether TAK-755, a lab-made protein that helps break up blood clots, is safe and effective for people who have had an acute ischemic stroke. About 222 adults aged 18 to 80 will receive either TAK-755 or a placebo, along with standard stroke care, and be monitored for 90 days. The main goal is to check for bleeding in the brain, while also seeing if the drug helps reduce stroke severity and improve daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TAK-755 (a lab-made version of a natural protein that helps break up blood clots)
What this could lead to: If it works, this could lead to a new treatment that helps people recover better after a stroke and reduces long-term disability.
What could go wrong: This is an early phase 2 trial with only 222 people, so results may not apply to everyone. There is also a risk of bleeding in the brain, which the study is carefully monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ISCHEMIC STROKE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AES - AS - KLES Dr Prabhakar Kore Hospital and Medical Research Centre
NOT_YET_RECRUITING

Belagavi, Karnataka, 590010, India
AHEPA University General Hospital of Thessaloniki
NOT_YET_RECRUITING

Thessaloniki, 54636, Greece
AZ Groeninge
NOT_YET_RECRUITING

Kortrijk, WVL, 8500, Belgium
Aberdeen Royal Infirmary
NOT_YET_RECRUITING

Cornhill, Aberdeen, AB25 2ZD, United Kingdom
All India Institute of Medical Sciences, New Delhi, Department of Neurology
NOT_YET_RECRUITING

New Delhi, 110029, India
Amrita Institute Of Medical Sciences and Research Centre
NOT_YET_RECRUITING

Kochi, Kerala, 682041, India
Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Raymond-Poincare
NOT_YET_RECRUITING

Garches, IDF, 92380, France
Athens Navy Hospital
NOT_YET_RECRUITING

Athens, 11521, Greece
Bangur Institute of Neurosciences
NOT_YET_RECRUITING

Kolkata, West Bengal, 700020, India
Bedfordshire Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Luton, Bedfordshire, LU4 0DZ, United Kingdom
Beijing Tiantan Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100070, China
Bicetre Hospital
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, IDF, 94270, France
CHU Bordeaux, CHU Pellegrin
NOT_YET_RECRUITING

Bordeaux, Aquitaine, 33076, France
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman
NOT_YET_RECRUITING

Liège, 4000, Belgium
Charite Universitatsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 12203, Germany
Christian Medical College, Ludhianana
NOT_YET_RECRUITING

Ludhiana, Punjab, 141008, India
Fukuoka Wajiro Hospital
RECRUITING

Fukuoka, Fukuoka, 811-0213, Japan
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
NOT_YET_RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Goethe-Universitaet-Universitaetsmedizin Frankfurt-Zentrum der Neurologie und Neurochirurgie (ZNN)
NOT_YET_RECRUITING

Frankfurt am Main, Hesse, 60590, Germany
Groupe Hospitalier Bichat Claude Bernard
NOT_YET_RECRUITING

Paris, IDF, 75018, France
Groupe sante CHC - Clinique du MontLegia
NOT_YET_RECRUITING

Liège, 4000, Belgium
HCA Houston Healthcare - North Cypress
NOT_YET_RECRUITING

Cypress, Texas, 77429, United States
HonorHealth Neurology
RECRUITING

Scottsdale, Arizona, 85251, United States
Hopital Lariboisiere
NOT_YET_RECRUITING

Paris, IDF, 78600, France
Hospital Das Clinicas da Faculdade de Medicina de Ribeirao Preto - Universidade de Sao Paulo
NOT_YET_RECRUITING

Ribeirão Preto, São Paulo, 14048-900, Brazil
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
Hospital Sao Paulo / Escola Paulista de Medicina da Universidade Federal de Sao Paulo (EPM/UNIFESP)
NOT_YET_RECRUITING

São Paulo, São Paulo, 04022-001, Brazil
Imperial College Healthcare NHS Trust, St. Mary's Hospital
NOT_YET_RECRUITING

London, W2 1NY, United Kingdom
Klinikum Ernst von Bergmann
NOT_YET_RECRUITING

Potsdam, Brandenburg, 14467, Germany
Kotobukikai Tominaga Hospital
NOT_YET_RECRUITING

Osaka, Osaka, 556-0017, Japan
Liaocheng People's Hospital
RECRUITING

Liaocheng, Shandong, 252000, China
Linfen Central Hospital
RECRUITING

Linfen, Shanxi, 041099, China
Linyi People's Hospital
RECRUITING

Linyi, Shandong, 276000, China
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
NHS Greater Glasgow and Clyde, Queen Elizabeth University Hospital
NOT_YET_RECRUITING

Glasgow, Lanarkshire, G51 4TF, United Kingdom
Nagano Municipal Hospital
RECRUITING

Nagano, Nagano, 381-8551, Japan
Nanshi Hospital of Nanyang
RECRUITING

Nanyang, Henan, 473003, China
Neurology Consultants of Dallas, PA
NOT_YET_RECRUITING

Dallas, Texas, 75243, United States
Porto Alegre Clinical Hospital (HCPA)
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Qilu Hospital of Shandong University
RECRUITING

Jinan, Shandong, 250012, China
Rinku General Medical Center
NOT_YET_RECRUITING

Izumisano, Osaka, 598-8577, Japan
Saiseikai Fukuoka General Hospital
RECRUITING

Fukuoka, Fukuoka, 810-0001, Japan
Second Department of Neurology, National and Kapodistrian University of Athens, "Attikon" University Hospital
NOT_YET_RECRUITING

Chaïdári, Attica, 12462, Greece
Sinopharm Tongmei General Hospital
RECRUITING

Datong, Shanxi, 037000, China
Technische Universitaet Dresden-Universitaetsklinikum Carl Gustav Carus
NOT_YET_RECRUITING

Dresden, Saxony, 01307, Germany
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, 221000, China
Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Medicina Campus de Botucatu
NOT_YET_RECRUITING

Botucatu, São Paulo, 18618-687, Brazil
Universidade Estadual de Campinas (UNICAMP)
NOT_YET_RECRUITING

Campinas, São Paulo, 13083-888, Brazil
Universitaetsklinikum Heidelberg (UKHD)
NOT_YET_RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
Universitaetsklinikum Tuebingen
NOT_YET_RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsmedizin Goettingen
NOT_YET_RECRUITING

Göttingen, Lower Saxony, 37075, Germany
Universitair Ziekenhuis Gent (Belgium,Ghent)
NOT_YET_RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
University Hospital of Alexandroupolis
NOT_YET_RECRUITING

Alexandroupoli, Evros, 68100, Greece
University at Buffalo
NOT_YET_RECRUITING

Buffalo, New York, 14202, United States
University of Arizona
NOT_YET_RECRUITING

Tucson, Arizona, 85724, United States
University of California San Francisco
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
University of Glasgow - PPDS
NOT_YET_RECRUITING

Glasgow, Lanarkshire, G4 0SF, United Kingdom
University of Pittsburgh Medical Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Ziekenhuis Oost-Limburg
NOT_YET_RECRUITING

Genk, Limburg, 3600, Belgium

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