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Metaverse meets microsurgery: XR platform aims to sharpen brain bypass precision

NCT ID NCT07711457

Disease control Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests a metaverse-based surgical platform that uses extended reality (XR) to help surgeons precisely locate blood vessels during brain bypass surgery. The trial includes 30 adults with moyamoya disease or chronic cerebral ischemia who need an extracranial-intracranial bypass. Before surgery, CT scans are loaded into the platform, and during the operation, XR overlays guide the surgeon to the donor and recipient arteries. The goal is to see if this technology improves localization accuracy and enables a less invasive approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NTU OpVerse surgical simulation platform, a metaverse-based extended reality system for surgical planning and guidance
What this could lead to
If successful, this platform could make brain bypass surgery more precise and less invasive, potentially improving safety and recovery for patients with moyamoya disease or chronic cerebral ischemia.
What could go wrong
This is a small early-stage study with only 30 participants, so results may not apply broadly. The technology may not improve outcomes enough to justify its use in routine surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include adult patients diagnosed with ischemic moyamoya disease, moyamoya syndrome, or chronic intracranial internal carotid artery stenosis or occlusion who are scheduled to undergo extracranial-intracranial bypass surgery. Eligible procedures include STA-MCA bypass, STA trunk-graft-MCA bypass, and other cerebral revascularization procedures using the superficial temporal artery or another branch of the external carotid artery as the donor vessel. Patients requiring emergency surgery, those with contraindications to CT imaging, severe systemic illness precluding follow-up assessment, scalp conditions or anatomical deformities preventing surface registration, or unreliable XR registration that may compromise surgical safety will be excluded.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients diagnosed with ischemic moyamoya disease, moyamoya syndrome, or chronic intracranial internal carotid artery stenosis or occlusion (chronic ICA stenosis/occlusion). * Patients scheduled to undergo extracranial-intracranial bypass surgery (EC-IC bypass), including superficial temporal artery-middle cerebral artery bypass (STA-MCA bypass), superficial temporal artery trunk-interposition graft-middle cerebral artery bypass (STA trunk-graft-MCA bypass), or other cerebral revascularization procedures using the superficial temporal artery or another branch of the external carotid artery system (STA/ECA system) as the donor blood supply. Exclusion Criteria: * Presence of a contraindication to computed tomography (CT) scanning. * Presence of a severe systemic illness that would prevent participation in subsequent study assessments, such as poorly controlled diabetes mellitus, active malignancy, or severe cardiac disease. * The need for emergency surgery without sufficient time to complete image-based modeling and registration. * Presence of scalp lesions, wounds, or anatomical deformities that prevent reliable surface registration. * The XR registration result is considered unreliable by the research team and may potentially compromise surgical safety.

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Conditions

The condition(s) this trial relates to.

brain ischemia carotid artery occlusion internal carotid artery stenosis Moyamoya disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Augmented reality Bypass surgery Chronic cerebral ischemia Extended reality (XR) Moyamoya disease

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Taiwan University Hospital

    RECRUITING

    Taipei, Taiwan

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