Could a heart drug save brains after a burst aneurysm?

NCT ID NCT07643922

Recruiting now Disease control Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospitals, comparing this endovascular therapy plus standard care against standard care alone. The main goal is to see if the treatment reduces the risk of severe disability or death within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Milrinone (given intra-arterially and intravenously)
What this could lead to: If it works, this could provide a proven treatment to reduce brain damage and disability after a bleeding stroke caused by a burst aneurysm.
What could go wrong: This is a relatively early randomized trial (306 participants) testing a drug already used off-label; results may not confirm benefit, and there are risks from the endovascular procedure itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage intracranial vasospasm subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CEREBRAL VASOSPASM AFTER SUBARACHNOID HEMORRHAGE SUBARACHNOID HEMORRHAGE, ANEURYSMAL

Contacts and locations

Locations

Beijing Tiantan Hospital
RECRUITING

Beijing, Beijing Municipality, 100070, China
Department of Neurosurgery, Beijing Tiantan Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100070, China

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