A simple gas flush before aortic repair might prevent strokes

NCT ID NCT07734584

Recruiting now Disease control Sponsor: University of Bologna Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing thoracic endovascular aortic repair (TEVAR). About 90 adults with aortic tears or aneurysms will be randomly assigned to receive either standard saline flushing or a carbon dioxide flush followed by saline. The main goal is to see if the CO₂ group has fewer brain lesions detected on MRI after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: carbon dioxide flushing of the stent-graft before implantation
What this could lead to: If it works, this simple flushing step could become a standard practice to lower the risk of stroke and silent brain damage during aortic stent-graft procedures.
What could go wrong: This is a relatively small, early-stage trial, and the benefit may not be large enough to justify the extra step. The procedure itself carries inherent risks of stroke and other complications regardless of flushing.

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Conditions

The condition(s) this trial relates to.

Aneurysm aortic aneurysm Flushing stroke disorder thoracic aortic aneurysm transient ischemic attack

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THORACIC AND THORACOABDOMINAL ANEURYSMS WITH CRAWFORD EXTENT I, II, III, OR IV TYPE B ACUTE AORTIC SYNDROME

Contacts and locations

Locations

A.S.S.T. Spedali Civili di Brescia
NOT_YET_RECRUITING

Brescia, Italy, 25123, Italy
Azienda Ospedaliero-Universitaria di Padova
NOT_YET_RECRUITING

Padova, Italy, 35128, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITING

Bologna, Italy, 40138, Italy
IRCCS Policlinico San Martino di Genova
NOT_YET_RECRUITING

Genova, Italy, 16132, Italy

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