Thoracic aortic aneurysm

This study follows 125 people who received a special stent graft (GORE TAG TBE) to treat a tear or bulge in the main artery near the heart (aortic arch). The goal is to see how well the device works and how safe it is over 5 to 10 years. Participants are treated as part of their …

This study follows 1,500 people who received a GORE® TAG® stent graft to treat aortic conditions like aneurysms or dissections. Researchers will monitor device performance and patient outcomes for up to 10 years. The goal is to confirm that this minimally invasive procedure remai…

This large trial tests two types of intravenous fluids given during heart surgery: hydroxyethyl starch (HES) and balanced crystalloids. The goal is to see which fluid leads to fewer serious kidney problems, such as kidney failure or death. About 1,292 adults having heart surgery …

This trial tests whether flushing a stent-graft with carbon dioxide before implanting it in the aorta can reduce the number of tiny air bubbles that travel to the brain during the procedure. These bubbles are a major cause of stroke and silent brain damage in patients undergoing …

This study tests a new device called Rapidlink, used during open surgery to repair or replace blood vessels in the chest. It involves 150 adults already scheduled for aortic surgery. The goal is to see if the device reduces major complications like stroke or death. Participants w…

This study tests a new device called the Arcevo LSA Hybrid Stent Graft, used during open surgery to repair the aortic arch in people with aneurysms or dissections. The device is implanted to support the aorta and its left subclavian artery branch. Researchers will track safety an…

This study compares two ways to keep blood flowing during open surgery for a large aneurysm in the chest and belly. About 236 adults will be randomly assigned to one of two heart-lung machine techniques. Researchers will track serious complications like death, stroke, kidney fail…

This registry is tracking how well two stent grafts, Castor and Cratos, work for treating aortic conditions like dissections and aneurysms. About 100 patients across European hospitals will be followed for up to 5 years. The goal is to see if these devices are safe and effective …

This study tests two types of branch endografts (Zenith t-Branch and Terumo Arch Branch) to treat aortic aneurysms in the chest and abdomen. The devices are placed inside the aorta to reinforce the weakened vessel wall and keep blood flowing to vital organs. Researchers will trac…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This study tests whether spironolactone, a medication that blocks aldosterone, can reduce stiffness in the aorta for people with a thoracic aortic aneurysm. About 50 adults with an enlarged aorta will receive either spironolactone or a placebo for a short time. The goal is to see…

This study follows 100 people with thoracoabdominal or pararenal aortic aneurysms who receive the GORE EXCLUDER TAMBE device, a stent-graft system placed through blood vessels. Researchers will track how often the device is successfully implanted and works without leaks or seriou…

This study tests a stent graft that doctors modify by hand to treat complex aortic aneurysms in patients who cannot use standard FDA-approved devices. About 40 high-risk adults will receive the custom graft and be followed for five years to check safety and effectiveness. The goa…

This study tests a new device called the WeFlow-Tribranch stent graft system to repair aneurysms or ulcers in the aortic arch. About 90 people aged 18 to 80 with these conditions will receive the stent through a minimally invasive procedure. The main goal is to see if the device …

This study compares two ways to treat complex abdominal aortic aneurysms (a bulging blood vessel in the belly). One method uses a custom-made stent-graft, the other uses a stent-graft shaped with the help of a 3D-printed model of the patient's aorta. The goal is to see which appr…

This study tests a special stent graft that doctors modify by hand to treat complex aortic aneurysms and dissections in patients who are too high-risk for standard surgery or devices. About 220 participants will be followed for up to 5 years to see if the procedure is safe and ef…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study is tracking 1,000 people who receive Terumo aortic stent grafts to repair aneurysms in the abdomen or chest. Researchers are monitoring how well the devices work and any complications, like death related to the aorta. It is an observational registry, meaning no new tre…

This study tests a minimally invasive procedure to treat large aneurysms in the aorta (the main artery) in the chest and belly area. Instead of open surgery, doctors place a fabric-covered metal tube (stent-graft) inside the aneurysm to seal it off. The goal is to see if this app…

This study is checking how well a device called the GORE® TAG® Thoracic Branch Endoprosthesis works for people with a thoracic aortic aneurysm, dissection, or injury. About 200 patients in Japan who receive this stent graft will be followed to see if it is safe and effective. The…

This study is testing a special stent-graft device to repair complex aneurysms in the aorta, the body's main artery. The device is inserted through leg arteries, avoiding open surgery. Researchers will track safety, survival, and quality of life in 760 people over time. The goal …

This study tracks 200 people with complex abdominal aortic aneurysms who receive a custom-made stent graft to reinforce the weakened artery. Researchers measure survival, major complications (like heart attack or stroke), and quality of life using a standard questionnaire. The go…

This study tests three custom-made stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce deaths, lung problems, and hospital stays. About 410 adults with certain types of aortic aneurysms will take part.

This study is testing a minimally invasive procedure using special stent-grafts to treat complex aortic aneurysms in the chest and abdomen. The procedure is designed for patients who are at high risk for traditional open surgery. Researchers will track how well the stents work an…

This study looks at whether specially modified stent grafts can safely treat complex aortic aneurysms (bulges in the main blood vessel) in people who are too high-risk for traditional open surgery. Researchers will track 50 patients to see how many have serious complications like…

This study is testing whether custom-made or physician-modified stent grafts can safely repair complex aortic aneurysms in people who cannot use standard devices or undergo open surgery. The grafts are tailored to each patient's anatomy, with small holes to keep blood flowing to …

This study tests a new surgical technique called B-SAFER for people with complex aortic disease affecting multiple segments of the aorta. The procedure combines open surgery with a modified stent graft to repair the aortic arch and descending aorta in one operation. Researchers a…

This study tests whether cooling patients to 32°C (mild) or 26°C (moderate) during aortic arch surgery better protects the brain and kidneys. 282 adults having planned aortic hemiarch surgery will be randomly assigned to one temperature. The goal is to see which temperature reduc…

This early-stage trial tests whether nicotinamide riboside (a form of vitamin B3) can improve blood flow and brain function in people with smooth muscle dysfunction syndrome (SMDS), a rare genetic condition that narrows arteries and can cause strokes. Fifteen participants will ta…

This early-stage trial is testing a new procedure called BAO-G for people with complex aortic aneurysms (bulging of the main artery in the chest and abdomen). The technique uses off-the-shelf stent grafts to rebuild the artery's branches from inside the blood vessel, avoiding maj…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests an artificial intelligence software called Aorta AIM that automatically measures the size of the aorta from CT scans. The aorta can enlarge over time, leading to serious health problems, and accurate measurement is key for monitoring. Researchers will compare the…

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study looks at 20 adults with COL5A gene mutations to find out why some get aortic aneurysms (a bulge in the main artery) and others don't. Researchers will take a small skin sample and study the cells to see differences in how they build and organize tissue. The goal is to …

This study asks 30 staff and students at the University of Nottingham to review draft recruitment materials for a future study on thoracic aortic disease. Participants will give feedback on how clear, easy to read, and appropriate the documents are. The goal is to improve these m…

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study tracks 300 adults with aortic disease to measure how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will use questionnaires over 12 months to gather data. The goal is to better understand these challenges and help desi…

This study is collecting information from 600 patients across Europe who receive custom-made stent-grafts from Cook to treat complex aortic aneurysms or chronic aortic dissections. The goal is to see how well these devices work in everyday medical practice and to track any major …

This study follows 320 people with small-to-moderate thoracic aortic aneurysms for up to 5 years. Researchers will track major complications like rupture or need for surgery, and look for factors such as high blood pressure or sleep problems that might speed up aneurysm growth. T…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study explores whether 3D printed models of a patient's own diseased aorta can help surgeons plan aneurysm surgery more effectively. Ten adults with thoracic or abdominal aortic aneurysms who are scheduled for non-emergency surgery will have their CT scans turned into physic…

This observational study aims to understand how lifestyle, stress, mental health, and other factors affect people with genetic aortic aneurysms. Researchers will survey 208 participants about their diagnosis journey, quality of life, and well-being. No treatments or drugs are bei…

This study looks at whether measuring a substance called presepsin in the blood during and after aorta surgery can help doctors decide when to use antibiotics. About 50 adults having surgery for a thoracic aortic aneurysm or dissection will take part. The goal is to see if presep…

This study installs a 'black box' recording system in hybrid operating rooms to capture and analyze errors during vascular procedures. Researchers will study how teamwork, leadership, and the environment affect surgical performance and patient safety. The goal is to identify high…