Thoracic aortic aneurysm

This study tests a new device called Rapidlink, used during open surgery to repair or replace blood vessels in the chest. It involves 150 adults already scheduled for aortic surgery. The goal is to see if the device reduces major complications like stroke or death. Participants w…

This study compares two ways to keep blood flowing during open surgery for a large aneurysm in the chest and belly. About 236 adults will be randomly assigned to one of two heart-lung machine techniques. Researchers will track serious complications like death, stroke, kidney fail…

This large trial tests two types of intravenous fluids given during heart surgery: hydroxyethyl starch (HES) and balanced crystalloids. The goal is to see which fluid leads to fewer serious kidney problems, such as kidney failure or death. About 1,292 adults having heart surgery …

This study follows 1,500 people who received a GORE® TAG® stent graft to treat aortic conditions like aneurysms or dissections. Researchers will monitor device performance and patient outcomes for up to 10 years. The goal is to confirm that this minimally invasive procedure remai…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This study follows 125 people who received a special stent graft (GORE TAG TBE) to treat a tear or bulge in the main artery near the heart (aortic arch). The goal is to see how well the device works and how safe it is over 5 to 10 years. Participants are treated as part of their …

This registry is tracking how well two stent grafts, Castor and Cratos, work for treating aortic conditions like dissections and aneurysms. About 100 patients across European hospitals will be followed for up to 5 years. The goal is to see if these devices are safe and effective …

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests two types of branch endografts (Zenith t-Branch and Terumo Arch Branch) to treat aortic aneurysms in the chest and abdomen. The devices are placed inside the aorta to reinforce the weakened vessel wall and keep blood flowing to vital organs. Researchers will trac…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study tests whether spironolactone, a medication that blocks aldosterone, can reduce stiffness in the aorta for people with a thoracic aortic aneurysm. About 50 adults with an enlarged aorta will receive either spironolactone or a placebo for a short time. The goal is to see…

This study tests a new device called the Arcevo LSA Hybrid Stent Graft, used during open surgery to repair the aortic arch in people with aneurysms or dissections. The device is implanted to support the aorta and its left subclavian artery branch. Researchers will track safety an…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study follows 100 people with thoracoabdominal or pararenal aortic aneurysms who receive the GORE EXCLUDER TAMBE device, a stent-graft system placed through blood vessels. Researchers will track how often the device is successfully implanted and works without leaks or seriou…

This study tests a stent graft that doctors modify by hand to treat complex aortic aneurysms in patients who cannot use standard FDA-approved devices. About 40 high-risk adults will receive the custom graft and be followed for five years to check safety and effectiveness. The goa…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests a new device called the WeFlow-Tribranch stent graft system to repair aneurysms or ulcers in the aortic arch. About 90 people aged 18 to 80 with these conditions will receive the stent through a minimally invasive procedure. The main goal is to see if the device …

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study compares two ways to treat complex abdominal aortic aneurysms (a bulging blood vessel in the belly). One method uses a custom-made stent-graft, the other uses a stent-graft shaped with the help of a 3D-printed model of the patient's aorta. The goal is to see which appr…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests a special stent graft that doctors modify by hand to treat complex aortic aneurysms and dissections in patients who are too high-risk for standard surgery or devices. About 220 participants will be followed for up to 5 years to see if the procedure is safe and ef…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study is tracking 1,000 people who receive Terumo aortic stent grafts to repair aneurysms in the abdomen or chest. Researchers are monitoring how well the devices work and any complications, like death related to the aorta. It is an observational registry, meaning no new tre…

This study tests a minimally invasive procedure to treat large aneurysms in the aorta (the main artery) in the chest and belly area. Instead of open surgery, doctors place a fabric-covered metal tube (stent-graft) inside the aneurysm to seal it off. The goal is to see if this app…

This study is checking how well a device called the GORE® TAG® Thoracic Branch Endoprosthesis works for people with a thoracic aortic aneurysm, dissection, or injury. About 200 patients in Japan who receive this stent graft will be followed to see if it is safe and effective. The…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study is testing a special stent-graft device to repair complex aneurysms in the aorta, the body's main artery. The device is inserted through leg arteries, avoiding open surgery. Researchers will track safety, survival, and quality of life in 760 people over time. The goal …

This study tracks 200 people with complex abdominal aortic aneurysms who receive a custom-made stent graft to reinforce the weakened artery. Researchers measure survival, major complications (like heart attack or stroke), and quality of life using a standard questionnaire. The go…

This study tests three custom-made stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce deaths, lung problems, and hospital stays. About 410 adults with certain types of aortic aneurysms will take part.

This study is testing a minimally invasive procedure using special stent-grafts to treat complex aortic aneurysms in the chest and abdomen. The procedure is designed for patients who are at high risk for traditional open surgery. Researchers will track how well the stents work an…

This study looks at whether specially modified stent grafts can safely treat complex aortic aneurysms (bulges in the main blood vessel) in people who are too high-risk for traditional open surgery. Researchers will track 50 patients to see how many have serious complications like…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study is testing whether custom-made or physician-modified stent grafts can safely repair complex aortic aneurysms in people who cannot use standard devices or undergo open surgery. The grafts are tailored to each patient's anatomy, with small holes to keep blood flowing to …

This study tests a new surgical technique called B-SAFER for people with complex aortic disease affecting multiple segments of the aorta. The procedure combines open surgery with a modified stent graft to repair the aortic arch and descending aorta in one operation. Researchers a…

This study tests whether cooling patients to 32°C (mild) or 26°C (moderate) during aortic arch surgery better protects the brain and kidneys. 282 adults having planned aortic hemiarch surgery will be randomly assigned to one temperature. The goal is to see which temperature reduc…

This early-stage trial tests whether nicotinamide riboside (a form of vitamin B3) can improve blood flow and brain function in people with smooth muscle dysfunction syndrome (SMDS), a rare genetic condition that narrows arteries and can cause strokes. Fifteen participants will ta…

This early-stage trial is testing a new procedure called BAO-G for people with complex aortic aneurysms (bulging of the main artery in the chest and abdomen). The technique uses off-the-shelf stent grafts to rebuild the artery's branches from inside the blood vessel, avoiding maj…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests an artificial intelligence software called Aorta AIM that automatically measures the size of the aorta from CT scans. The aorta can enlarge over time, leading to serious health problems, and accurate measurement is key for monitoring. Researchers will compare the…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study looks at 20 adults with COL5A gene mutations to find out why some get aortic aneurysms (a bulge in the main artery) and others don't. Researchers will take a small skin sample and study the cells to see differences in how they build and organize tissue. The goal is to …

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study asks 30 staff and students at the University of Nottingham to review draft recruitment materials for a future study on thoracic aortic disease. Participants will give feedback on how clear, easy to read, and appropriate the documents are. The goal is to improve these m…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study tracks 300 adults with aortic disease to measure how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will use questionnaires over 12 months to gather data. The goal is to better understand these challenges and help desi…

This study is collecting information from 600 patients across Europe who receive custom-made stent-grafts from Cook to treat complex aortic aneurysms or chronic aortic dissections. The goal is to see how well these devices work in everyday medical practice and to track any major …

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study follows 320 people with small-to-moderate thoracic aortic aneurysms for up to 5 years. Researchers will track major complications like rupture or need for surgery, and look for factors such as high blood pressure or sleep problems that might speed up aneurysm growth. T…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study explores whether 3D printed models of a patient's own diseased aorta can help surgeons plan aneurysm surgery more effectively. Ten adults with thoracic or abdominal aortic aneurysms who are scheduled for non-emergency surgery will have their CT scans turned into physic…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This observational study aims to understand how lifestyle, stress, mental health, and other factors affect people with genetic aortic aneurysms. Researchers will survey 208 participants about their diagnosis journey, quality of life, and well-being. No treatments or drugs are bei…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study looks at whether measuring a substance called presepsin in the blood during and after aorta surgery can help doctors decide when to use antibiotics. About 50 adults having surgery for a thoracic aortic aneurysm or dissection will take part. The goal is to see if presep…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study installs a 'black box' recording system in hybrid operating rooms to capture and analyze errors during vascular procedures. Researchers will study how teamwork, leadership, and the environment affect surgical performance and patient safety. The goal is to identify high…

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…