Cooler or warmer? new trial tests best temperature for aortic surgery safety

NCT ID NCT02860364

Recruiting now Disease control Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether cooling patients to 32°C (mild) or 26°C (moderate) during aortic arch surgery better protects the brain and kidneys. 282 adults having planned aortic hemiarch surgery will be randomly assigned to one temperature. The goal is to see which temperature reduces complications like stroke and kidney injury.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hypothermia (mild or moderate) during surgery
What this could lead to: If mild hypothermia works better, it could reduce brain and kidney damage after aortic surgery, leading to safer procedures and faster recovery.
What could go wrong: This is a mid-stage trial with 282 patients, so results may not apply to all. The difference between mild and moderate cooling might be small, and there are always risks from major surgery itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic disorder thoracic aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THORACIC AORTIC DISEASE

Contacts and locations

Locations

Dalhousie university
NOT_YET_RECRUITING

Halifax, Nova Scotia, B3H 3A7, Canada
Fraser Health Authority
RECRUITING

Surrey, British Columbia, V3T 0H1, Canada
Institut universitaire de cardiologie et de pneumologie de Québec
RECRUITING

Québec, Quebec, G1V 4G5, Canada
Kelowna General Hospital
RECRUITING

Kelowna, British Columbia, V1Y 1T2, Canada
London Health Sciences Centre
RECRUITING

London, Ontario, N6A 5A5, Canada
Massachusetts General
RECRUITING

Boston, Massachusetts, 02114, United States
Montreal Heart Institute
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Ohio State University Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
The Valley Hospital
RECRUITING

Ridgewood, New Jersey, 07450, United States
University Health Network
RECRUITING

Toronto, Ontario, M5G 2N2, Canada
University of British Columbia
NOT_YET_RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada

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