Custom stent grafts offer new hope for High-Risk aneurysm patients

NCT ID NCT02050113

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether custom-made or physician-modified stent grafts can safely repair complex aortic aneurysms in people who cannot use standard devices or undergo open surgery. The grafts are tailored to each patient's anatomy, with small holes to keep blood flowing to vital organs. The trial includes 600 participants with various aneurysm types and connective tissue disorders like Marfan syndrome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Custom-made or physician-modified stent grafts (devices placed in blood vessels to repair aneurysms)

What this could lead to

If successful, this approach could offer a safer, less invasive treatment option for people with complex aortic aneurysms who cannot have standard surgery or commercial grafts.

What could go wrong

This is an early-stage study with no control group, so results may not apply to everyone. Risks include serious complications like stroke, paralysis, or bleeding.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

abdominal aortic aneurysm Aneurysm, Aortic Arch aortic aneurysm Aortic Dissection Ehlers-Danlos syndrome Loeys-Dietz syndrome Marfan syndrome thoracic aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UMass Memorial Health Care - University Campus

    RECRUITING

    Worcester, Massachusetts, 01655, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••