Custom stent grafts offer new hope for High-Risk aneurysm patients

NCT ID NCT02050113

Recruiting now Disease control Sponsor: Andres Schanzer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether custom-made or physician-modified stent grafts can safely repair complex aortic aneurysms in people who cannot use standard devices or undergo open surgery. The grafts are tailored to each patient's anatomy, with small holes to keep blood flowing to vital organs. The trial includes 600 participants with various aneurysm types and connective tissue disorders like Marfan syndrome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Custom-made or physician-modified stent grafts (devices placed in blood vessels to repair aneurysms)
What this could lead to: If successful, this approach could offer a safer, less invasive treatment option for people with complex aortic aneurysms who cannot have standard surgery or commercial grafts.
What could go wrong: This is an early-stage study with no control group, so results may not apply to everyone. Risks include serious complications like stroke, paralysis, or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal aortic aneurysm Aneurysm, Aortic Arch aortic aneurysm Aortic Dissection Ehlers-Danlos syndrome Loeys-Dietz syndrome Marfan syndrome thoracic aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC ARCH ANEURYSM COMPLEX AORTIC ANEURYSMS EHLERS-DANLOS SYNDROME JUXTARENAL ANEURYSMS LOEYS-DIETZ SYNDROME MARFAN SYNDROME PARARENAL ANEURYSMS THORACOABDOMINAL ANEURYSMS

Contacts and locations

Locations

UMass Memorial Health Care - University Campus
RECRUITING

Worcester, Massachusetts, 01655, United States

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