Blood test may predict aneurysm surgery need in marfan patients

NCT ID NCT05700175

Ongoing Knowledge-focused Sponsor: IRCCS Policlinico S. Donato Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with stable aneurysms, and those needing surgery. By analyzing gene activity and other molecules, they hope to find a signature that improves current monitoring and treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a blood test that helps doctors predict which Marfan patients need aortic surgery earlier.
What could go wrong: This is an observational study, not a treatment trial. It may not find clear biomarkers, and any future test would require years of additional validation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Marfan syndrome thoracic aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MARFAN SYNDROME MARFAN'S SYNDROME WITH CARDIOVASCULAR MANIFESTATIONS

Contacts and locations

Locations

Irccs Policlinico San Donato

San Donato Milanese, Milan, 20097, Italy

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