Irccs Policlinico S. Donato

This study is testing the Navitor heart valve in 1000 people with severe aortic stenosis, a condition where the heart's main valve narrows. Participants receive the valve through a catheter, and researchers track survival and complications for one year. The goal is to see how wel…

This study looks at people with narrowed carotid arteries who are getting a stent. Some people do not respond well to the common blood thinner clopidogrel. The study compares giving these 'non-responders' a different drug, ticagrelor, versus continuing clopidogrel in those who re…

This study is testing a device called JenaValve Trilogy to replace the aortic valve without open-heart surgery in 75 people with severe aortic regurgitation (a leaky heart valve). Participants are at high risk for surgery. The main goal is to see if the device works safely and st…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery starts in the wrong place (AAOCA), which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and pr…

This study tests whether applying Prontosan Wound Gel X during heart surgery can reduce the chance of wound infections. About 456 adults having planned heart surgery will receive the gel, and researchers will track infection rates during their hospital stay. The goal is to see if…

This study tests whether a nerve block (rectus sheath block) can control pain after open abdominal aortic aneurysm repair as well as the standard epidural analgesia, but with fewer complications. About 60 adults undergoing elective surgery will be randomly assigned to one of the …

This study tests whether a new laboratory method—staining for a protein called claudin 2—can more accurately measure healing in the gut of people with ulcerative colitis or Crohn's disease. Researchers will compare this method with standard scoring systems and track whether it pr…

This study looks at how the brain, heart, and blood vessels interact in healthy adults. Researchers will measure heart activity, brain waves, blood pressure, and blood flow while participants rest, stand up, and watch emotional videos. The goal is to better understand the body's …

This study looks at how the body's automatic systems control heart rate, blood pressure, and blood flow to the brain when a person stands up. Sixty healthy adults will have their heart activity, blood pressure, brain blood velocity, and breathing recorded while lying down and the…

This study investigates whether monitoring brain blood flow during heart surgery can help predict strokes afterward. Researchers will use non-invasive sensors to track how well the brain regulates its own blood supply during different phases of surgery. The goal is to develop a m…

This study looks at how well people with Anderson-Fabry disease can exercise and how their hearts respond to stress. Researchers will use treadmill tests, echocardiograms, and heart scans to measure heart function during rest and exercise. The goal is to find better ways to detec…

This study looks at 20 adults with COL5A gene mutations to find out why some get aortic aneurysms (a bulge in the main artery) and others don't. Researchers will take a small skin sample and study the cells to see differences in how they build and organize tissue. The goal is to …

This study compares different types of heart valve prostheses used to treat severe aortic stenosis in people with a small aortic annulus. Researchers will test the valves in the lab and then in patients using echocardiograms and a special MRI scan that measures blood flow. The go…

This study looks at whether a gene called TMEM230 plays a role in atherosclerosis, the buildup of fatty plaques in arteries that can lead to heart attacks and strokes. Researchers will collect blood and artery tissue from 12 adults undergoing vascular surgery. They aim to underst…

This study looks at how the brain, nerves, and blood vessels interact in 80 adults having heart surgery. Researchers will measure brain activity, blood flow, and heart reflexes to better understand the link between heart disease and depression. The goal is to develop new tools fo…

This study looks at tissue removed from patients with enlarged aortas (aneurysms) during surgery. Researchers want to measure how strong the tissue is and see if that relates to the size or thickness of the aorta. The goal is to better understand what makes an aneurysm likely to …

This study is testing a new way to use MRI scans to measure how well the heart's main pumping chamber works in people with severe aortic stenosis who are scheduled for valve replacement. Researchers will develop computer models to automatically analyze heart images and compare th…

This study is looking for better, cheaper ways to detect Alzheimer's disease early. Researchers will collect blood samples, brain wave recordings, and speech recordings from 250 people who have noticed memory problems but still function normally. They will use machine learning to…

This observational study aims to understand how lifestyle, stress, mental health, and other factors affect people with genetic aortic aneurysms. Researchers will survey 208 participants about their diagnosis journey, quality of life, and well-being. No treatments or drugs are bei…

This study is developing an artificial intelligence (AI) system to automatically analyze 3D ultrasound images of the heart in people with mitral valve prolapse, a condition where a heart valve doesn't close properly. The AI will measure the valve's shape and movement, and create …

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This observational study is measuring arterial stiffness in 250 people with genetic conditions that cause aortic aneurysms. Researchers want to see if stiffness can help predict who is at higher risk. Participants undergo a simple, non-invasive test of blood pressure and artery s…