Irccs Policlinico S. Donato

This study is testing a new device called the JenaValve Trilogy to replace a leaky heart valve without open-heart surgery. It includes 75 people with severe aortic regurgitation who are too high-risk for surgery. The goal is to see if the device is safe and works well at 12 month…

This study is testing a new heart valve called Navitor in 1000 people with severe aortic stenosis, a condition where the heart's main valve is narrowed. Participants will receive the valve through a less invasive procedure and be followed for 12 months to see how they do. The goa…

This study aims to speed up and improve the diagnosis of a rare heart condition where a coronary artery grows from the wrong spot, which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and p…

This study looks at how stiff the arteries are in people who have a genetic condition that causes a bulge in the main artery (aortic aneurysm). Researchers want to see if measuring artery stiffness can help predict who is at higher risk. About 250 participants will have non-invas…

This study is testing whether adding genetic and imaging information to standard risk tools can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants are grouped by current risk level and followed for one year to see if the extra data leads to imp…

This study looks at how lifestyle, stress, emotions, and health habits affect people with genetic aortic aneurysms. Researchers will track 208 participants to understand connections between daily life and heart risks. The goal is to find new risk factors and improve care for this…

This study uses a special MRI technique (4D Flow) to measure how well the left ventricle pumps blood in people with severe aortic valve narrowing who are scheduled for valve replacement. Researchers will develop computer models to automatically analyze heart images and compare th…

This study looks at pieces of the aorta (the main artery from the heart) that are removed during surgery in people with an aortic aneurysm. Researchers will test how strong the tissue is and how it stretches, to better understand when an aneurysm might burst. The goal is to impro…

This study looks at how a gene called TMEM230 may be involved in atherosclerosis, the buildup of fatty plaques in arteries that can lead to heart attacks and strokes. Researchers will analyze blood and tissue samples from 12 adults having vascular surgery to measure gene activity…

This study aims to find better, cheaper ways to detect Alzheimer's disease early in people who have memory concerns but still function normally. Researchers will collect blood, brain wave recordings, speech samples, and genetic data from 250 participants. They will use machine le…

This study is developing an artificial intelligence (AI) system to automatically analyze 3D ultrasound images of the heart in people with mitral valve prolapse, a condition where a heart valve doesn't close properly. The goal is to create detailed 3D models of the valve to help s…

This study looks at how the brain, nervous system, and blood vessels work together in 80 adults having heart surgery. The goal is to better understand the link between heart disease and depression. Researchers will measure brain waves, heart rate control, and blood flow before an…