Thoracic aortic aneurysm

This study tests a special stent device (GORE EXCLUDER) to treat thoracoabdominal and pararenal aortic aneurysms—bulges in the main artery that can rupture. About 102 people will receive the stent through a minimally invasive procedure. Researchers will check if the device is pla…

This study tests a special tube called a stent graft to repair damage in the upper part of the main artery from the heart (the ascending aorta). It is for people with bulges (aneurysms), tears (dissections), or other lesions that usually need open-heart surgery. The goal is to se…

This study is following 147 people who have a bulge (aneurysm) or tear (dissection) in the main artery of the chest. All participants received the Ankura stent graft, a fabric-covered metal tube placed inside the artery to support it. Researchers are tracking how well the device …

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This study looks at how well new, custom-made and off-the-shelf stent-grafts work for repairing complex aortic aneurysms (bulges in the main artery). About 750 people with aneurysms in the abdomen, chest, or arch will be treated using a less invasive procedure through blood vesse…

This study is testing a less invasive procedure using stent-grafts to treat various types of aortic disease, including aneurysms and dissections. It involves 170 participants who are considered too high-risk for traditional open surgery. The goal is to see if this endovascular ap…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study is testing a new stent device called the GORE® TAG® Thoracic Branch Endoprosthesis to treat aneurysms or lesions in the aortic arch and upper part of the main artery from the heart. About 250 participants will receive the device to see if it is safe and effective. The …

This study provides expanded access to a new device called the GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis for people with thoracoabdominal or pararenal aortic aneurysms. These are bulges in the main artery that involve branches to vital organs. The device is a stent-gra…

This study is testing a device called the E-nside stent graft system in 30 people with thoracoabdominal aortic aneurysms (a bulge in the main artery that runs through the chest and belly). The goal is to see if the device is safe and works well when placed inside the artery to re…

This study follows 300 people who received the GORE TAMBE device to treat complex aortic aneurysms. The goal is to confirm the device works safely and effectively outside of clinical trials. Researchers will track technical success and patient outcomes over 12 months.

This observational study follows 352 adults with aortic arch or descending aorta disease who receive the Thoraflex Hybrid device, sometimes with an additional RelayPro stent-graft. The goal is to evaluate safety and treatment success over 10 years, including risks like stroke, sp…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study planned to test a branched stent-graft for treating aneurysms in the aortic arch, a high-risk area near the heart. The goal was to see if the device could be safely placed and hold up over time. However, the study was withdrawn before enrolling any participants, so no …

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study looks at skin cells (fibroblasts) from people with Marfan syndrome and other genetic conditions that cause thoracic aortic aneurysms (a bulging of the main artery in the chest). Researchers want to find out how these cells behave differently and what genes or proteins …

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study follows 770 people who had aortic aneurysm repair using branched stent grafts. Researchers will check kidney function and other organ health over two years to see how different stent designs affect outcomes. The goal is to learn which approaches work best for preservin…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study from Mayo Clinic aims to see how common a widened aorta (thoracic aorta dilatation) is among experienced weightlifters over age 35. Researchers will use ultrasound to measure the aorta in 45 participants who have been lifting weights for at least 5 years. The goal is s…

This study follows 300 people who already received a Zenith® Alpha Thoracic Endovascular Graft to treat a thoracic aortic aneurysm or ulcer. Researchers are checking how well the device works and how safe it is over the long term, especially looking at deaths related to the aorti…

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study aimed to create a 12-month profile of patients admitted for vascular surgery at University Hospital Limerick in Ireland. The goal was to understand patient characteristics like frailty and other health conditions to improve hospital services and reduce length of stay. …

This observational study examines how the nervous system works in 139 adults with thoracic aortic aneurysms (a bulge in the chest's main artery). Participants lie down and then stand while their blood pressure and breathing are monitored non-invasively. The goal is to see if nerv…