Could a vitamin B3 pill help rare artery disorder?
NCT ID NCT06280482
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-stage trial tests whether nicotinamide riboside (a form of vitamin B3) can improve blood flow and brain function in people with smooth muscle dysfunction syndrome (SMDS), a rare genetic condition that narrows arteries and can cause strokes. Fifteen participants will take a daily pill for 60 days. Researchers will check safety, blood vessel size, and thinking skills.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nicotinamide riboside (a form of vitamin B3)
- What this could lead to
- If it works, this could point toward a treatment to stabilize blood vessels and improve brain function in people with SMDS.
- What could go wrong
- This is a very early Phase 1 trial with only 15 people. It is testing safety and basic effects, not whether it truly helps the disease long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SMOOTH MUSCLE DYSFUNCTION SYNDROME (SMDS) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States