New eye drug combo aims to tackle Diabetes-Related vision loss

NCT ID NCT07425522

Recruiting now Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study will enroll 93 participants to check safety, side effects, and how the drug behaves in the body. It is not yet known if the drug improves vision, as the main goal is to find a safe dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RO7823653 (an experimental drug) and faricimab (an approved drug), both given as eye injections
What this could lead to: If successful, this could point toward a new treatment option for diabetic macular edema that may help reduce retinal swelling and improve vision.
What could go wrong: This is a very early Phase 1 trial with only 93 participants, focused on safety. The drug may not work or could cause side effects like eye inflammation or infection from the injections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Locations

Associated Retina Consultants - Peoria - DocTrials - PPDS
RECRUITING

Peoria, Arizona, 85381-3690, United States
Austin Clinical Research, LLC
RECRUITING

Austin, Texas, 78750-2298, United States
Bay Area Retina Specialists Medical Group - Vestrum - PPDS
RECRUITING

Walnut Creek, California, 94598-5915, United States
Charles Retina Institute
RECRUITING

Germantown, Tennessee, 38138-2405, United States
Erie Retina Research, LLC - 300 State St
RECRUITING

Erie, Pennsylvania, 16507-1429, United States
Piedmont Eye Center
RECRUITING

Lynchburg, Virginia, 24502-4271, United States
Retina Consultants of Texas Westover Hills Retina Center
RECRUITING

San Antonio, Texas, 78251, United States
Retina Research Institute of Texas
RECRUITING

Abilene, Texas, 79606-1224, United States
Retina Vitreous Associates of Florida
RECRUITING

St. Petersburg, Florida, 33711-1141, United States
Retina-Vitreous Associates Medical Group
RECRUITING

Beverly Hills, California, 90211-1838, United States
Wills Eye Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107-5109, United States
Wilmer Eye Institute
RECRUITING

Baltimore, Maryland, 21287-0005, United States

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