New eye drug combo aims to tackle Diabetes-Related vision loss
NCT ID NCT07425522
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study will enroll 93 participants to check safety, side effects, and how the drug behaves in the body. It is not yet known if the drug improves vision, as the main goal is to find a safe dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RO7823653 (an experimental drug) and faricimab (an approved drug), both given as eye injections
What this could lead to
If successful, this could point toward a new treatment option for diabetic macular edema that may help reduce retinal swelling and improve vision.
What could go wrong
This is a very early Phase 1 trial with only 93 participants, focused on safety. The drug may not work or could cause side effects like eye inflammation or infection from the injections.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Associated Retina Consultants - Peoria - DocTrials - PPDS
RECRUITINGPeoria, Arizona, 85381-3690, United States
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Austin Clinical Research, LLC
RECRUITINGAustin, Texas, 78750-2298, United States
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Bay Area Retina Specialists Medical Group - Vestrum - PPDS
RECRUITINGWalnut Creek, California, 94598-5915, United States
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Charles Retina Institute
RECRUITINGGermantown, Tennessee, 38138-2405, United States
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Erie Retina Research, LLC - 300 State St
RECRUITINGErie, Pennsylvania, 16507-1429, United States
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Piedmont Eye Center
RECRUITINGLynchburg, Virginia, 24502-4271, United States
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Retina Consultants of Texas Westover Hills Retina Center
RECRUITINGSan Antonio, Texas, 78251, United States
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Retina Research Institute of Texas
RECRUITINGAbilene, Texas, 79606-1224, United States
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Retina Vitreous Associates of Florida
RECRUITINGSt. Petersburg, Florida, 33711-1141, United States
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Retina-Vitreous Associates Medical Group
RECRUITINGBeverly Hills, California, 90211-1838, United States