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New eye drug could cut injection frequency for Diabetes-Related vision loss

NCT ID NCT07449936

Recruiting now Disease control Sponsor: EyePoint Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision over a year. The goal is to see if EYP-1901 can control DME with fewer injections than current treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

EYP-1901 (a tyrosine kinase inhibitor) and aflibercept

What this could lead to

If successful, EYP-1901 could offer a longer-lasting treatment for diabetic macular edema, reducing the number of eye injections needed to control vision loss.

What could go wrong

This is a phase 3 trial, but results may not show EYP-1901 is as effective as aflibercept. Risks include eye inflammation, infection, or vision changes from the injection.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cystoid macular edema diabetes mellitus diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA DIABETIC MACULAR EDEMA (DME) DME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Advance Medical Research Group, Inc

    RECRUITING

    Deerfield Beach, Florida, 33064, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Asheville Eye Associates - Regional Medical Park

    RECRUITING

    Asheville, North Carolina, 28803, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Augenklinik Universitaetsmedizin der Johannes Gutenberg-Univ.

    RECRUITING

    Mainz, Germany

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Bnai Zion Medical Center

    RECRUITING

    Haifa, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • California Eye Specialists Medical Group, Inc.

    RECRUITING

    Redlands, California, 92373, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • California Retina Consultants

    RECRUITING

    Bakersfield, California, 93309, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cape Fear Retinal Associates, PC

    RECRUITING

    Wilmington, North Carolina, 28401, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Carmel Medical Center

    RECRUITING

    Haifa, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centrum Diagnostyki i Mikrochirurgii Oka -LENS Sp. z o. o

    RECRUITING

    Olsztyn, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centrum Medyczne UNO-MED

    RECRUITING

    Tarnów, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Charleston Neuroscience Institute - Beaufort

    RECRUITING

    Beaufort, South Carolina, 29902, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Colorado Retina Associates

    RECRUITING

    Lakewood, Colorado, 80228, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cumberland Valley Retina Consultants

    COMPLETED

    Hagerstown, Maryland, 21740, United States

  • Erie Retina Research

    RECRUITING

    Erie, Pennsylvania, 16507, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Eye Associates of Pinellas

    RECRUITING

    Pinellas Park, Florida, 33782, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Foundation for Vision Research

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Georgia Retina

    RECRUITING

    Marietta, Georgia, 30060, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Global Research Management, Inc.

    RECRUITING

    Glendale, California, 91204, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Haik Humble Eye Center

    RECRUITING

    West Monroe, Louisiana, 71291, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Kaplan Medical Center

    RECRUITING

    Rehovot, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Meir Medical Center Ophthalmology Department

    RECRUITING

    Kfar Saba, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Midwest Eye Institute - Carmel

    RECRUITING

    Carmel, Indiana, 11220, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mt. Olympus Medical Research

    RECRUITING

    Houston, Texas, 77479, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NJ Retina - Toms River

    RECRUITING

    Toms River, New Jersey, 08755, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NJRetina Care Center - Teaneck

    RECRUITING

    Teaneck, New Jersey, 07666, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nemocnica s poliklinikou Trebisov a.s.

    RECRUITING

    Trebišov, Slovakia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • New England Retina Consultants

    RECRUITING

    Springfield, Massachusetts, 01107, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Northeast Wisconsin Retina Associates

    RECRUITING

    Appleton, Wisconsin, 54914, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Northern California Retina Vitreous Associates Medical Group INC.

    RECRUITING

    Mountain View, California, 94040, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • OFTALMIKA Sp. z o.o

    RECRUITING

    Bydgoszcz, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Piedmont Eye Center

    RECRUITING

    Lynchburg, Virginia, 24502, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Piedmont Retina Specialists, P.A. - Winston-Salem Office

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Rabin Medical Center

    RECRUITING

    Petah Tikva, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Rambam Health Care Campus (RHCC)

    RECRUITING

    Haifa, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Red River Research Partners

    RECRUITING

    Plainfield, Illinois, 60586, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Associates of Michigan

    RECRUITING

    Grand Blanc, Michigan, 48439, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Associates of Utah

    RECRUITING

    Salt Lake City, Utah, 84107, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Associates of Western New York

    RECRUITING

    Rochester, New York, 14620, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Consultants of Carolina P.A

    RECRUITING

    Greenville, South Carolina, 29605, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Consultants of Hawaii

    RECRUITING

    ‘Aiea, Hawaii, 96701, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Consultants of San Diego

    RECRUITING

    Poway, California, 92064, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Consultants of Southern Colorado

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Consultants of Texas

    RECRUITING

    Katy, Texas, 77494, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Consultants of Texas

    RECRUITING

    Schertz, Texas, 78154, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Group of Washington

    RECRUITING

    Chevy Chase, Maryland, 20815, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Research Institute of Texas Integrated Clinical Research

    RECRUITING

    Abilene, Texas, 79606, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Specialists - Towson

    RECRUITING

    Towson, Maryland, 21204, United States

  • Retina Specialists of Tampa

    RECRUITING

    Wesley Chapel, Florida, 33544, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retina Vitreous Associates of Florida - Saint Petersburg

    RECRUITING

    St. Petersburg, Florida, 33711, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retinal Consultants Medical Group

    RECRUITING

    Sacramento, California, 95841, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Retinal Consultants Medical Group - Parkcenter Drive

    RECRUITING

    Sacramento, California, 95825, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Salt Lake Retina

    RECRUITING

    West Jordan, Utah, 84088, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie

    RECRUITING

    Lublin, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Shamir Medical Center Ophthalmology Out Patient Clinic

    RECRUITING

    Be’er Ya‘aqov, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sierra Eye Associates

    RECRUITING

    Reno, Nevada, 89502, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Southern Vitreoretinal Associates

    RECRUITING

    Tallahassee, Florida, 32308, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Tennessee Retina

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Retina Associates

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Texas Retina Associates

    RECRUITING

    Plano, Texas, 75075, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Retina Partners

    RECRUITING

    Encino, California, 91436, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Tel-Aviv Sourasky Medical Centre

    RECRUITING

    Tel Aviv, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Tulsa Retina Consultant

    RECRUITING

    Tulsa, Oklahoma, 74114, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • VRCNY/Long Island Vitreoretinal Consultants

    RECRUITING

    Westbury, New York, 11590, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Virginia Retina Center

    RECRUITING

    Warrenton, Virginia, 20186, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Warszawski Szpital Okulistyczny

    RECRUITING

    Warsaw, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••