New eye drug could cut injection frequency for Diabetes-Related vision loss

NCT ID NCT07449936

Recruiting now Disease control Sponsor: EyePoint Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 5 times

Summary

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision over a year. The goal is to see if EYP-1901 can control DME with fewer injections than current treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: EYP-1901 (a tyrosine kinase inhibitor) and aflibercept
What this could lead to: If successful, EYP-1901 could offer a longer-lasting treatment for diabetic macular edema, reducing the number of eye injections needed to control vision loss.
What could go wrong: This is a phase 3 trial, but results may not show EYP-1901 is as effective as aflibercept. Risks include eye inflammation, infection, or vision changes from the injection.

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Conditions

The condition(s) this trial relates to.

cystoid macular edema diabetes mellitus diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA DIABETIC MACULAR EDEMA (DME) DME

Contacts and locations

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Locations

Advance Medical Research Group, Inc
RECRUITING

Deerfield Beach, Florida, 33064, United States

Contact Email: •••••@•••••
Advanced Research LLC Sibia Eye Institute
RECRUITING

Boynton Beach, Florida, 33437, United States

Contact Email: •••••@•••••
Asheville Eye Associates - Regional Medical Park
RECRUITING

Asheville, North Carolina, 28803, United States

Contact Email: •••••@•••••
Augenklinik Universitaetsmedizin der Johannes Gutenberg-Univ.
RECRUITING

Mainz, Germany

Contact Email: •••••@•••••
Bnai Zion Medical Center
RECRUITING

Haifa, Israel

Contact Email: •••••@•••••
California Eye Specialists Medical Group, Inc.
RECRUITING

Redlands, California, 92373, United States

Contact Email: •••••@•••••
California Retina Consultants
RECRUITING

Bakersfield, California, 93309, United States

Contact Email: •••••@•••••
Cape Fear Retinal Associates, PC
RECRUITING

Wilmington, North Carolina, 28401, United States

Contact Email: •••••@•••••
Carmel Medical Center
RECRUITING

Haifa, Israel

Contact Email: •••••@•••••
Centrum Diagnostyki i Mikrochirurgii Oka -LENS Sp. z o. o
RECRUITING

Olsztyn, Poland

Contact Email: •••••@•••••
Centrum Medyczne UNO-MED
RECRUITING

Tarnów, Poland

Contact Email: •••••@•••••
Charleston Neuroscience Institute - Beaufort
RECRUITING

Beaufort, South Carolina, 29902, United States

Contact Email: •••••@•••••
Colorado Retina Associates
RECRUITING

Lakewood, Colorado, 80228, United States

Contact Email: •••••@•••••
Cumberland Valley Retina Consultants
COMPLETED

Hagerstown, Maryland, 21740, United States
Erie Retina Research
RECRUITING

Erie, Pennsylvania, 16507, United States

Contact Email: •••••@•••••
Eye Associates of Pinellas
RECRUITING

Pinellas Park, Florida, 33782, United States

Contact Email: •••••@•••••
Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica
RECRUITING

Banská Bystrica, Slovakia

Contact Email: •••••@•••••
Foundation for Vision Research
RECRUITING

Grand Rapids, Michigan, 49546, United States

Contact Email: •••••@•••••
Georgia Retina
RECRUITING

Marietta, Georgia, 30060, United States

Contact Email: •••••@•••••
Global Research Management, Inc.
RECRUITING

Glendale, California, 91204, United States

Contact Email: •••••@•••••
Haik Humble Eye Center
RECRUITING

West Monroe, Louisiana, 71291, United States

Contact Email: •••••@•••••
Johns Hopkins Medicine - The Johns Hopkins Hospital Campus - Wilmer Eye Institute
RECRUITING

Baltimore, Maryland, 21287, United States

Contact Email: •••••@•••••
Kaplan Medical Center
RECRUITING

Rehovot, Israel

Contact Email: •••••@•••••
Meir Medical Center Ophthalmology Department
RECRUITING

Kfar Saba, Israel

Contact Email: •••••@•••••
Midwest Eye Institute - Carmel
RECRUITING

Carmel, Indiana, 11220, United States

Contact Email: •••••@•••••
Mt. Olympus Medical Research
RECRUITING

Houston, Texas, 77479, United States

Contact Email: •••••@•••••
NJ Retina - Toms River
RECRUITING

Toms River, New Jersey, 08755, United States

Contact Email: •••••@•••••
NJRetina Care Center - Teaneck
RECRUITING

Teaneck, New Jersey, 07666, United States

Contact Email: •••••@•••••
Nemocnica Poprad
RECRUITING

Poprad, Slovakia

Contact Email: •••••@•••••
Nemocnica s poliklinikou Trebisov a.s.
RECRUITING

Trebišov, Slovakia

Contact Email: •••••@•••••
New England Retina Consultants
RECRUITING

Springfield, Massachusetts, 01107, United States

Contact Email: •••••@•••••
Northeast Wisconsin Retina Associates
RECRUITING

Appleton, Wisconsin, 54914, United States

Contact Email: •••••@•••••
Northern California Retina Vitreous Associates Medical Group INC.
RECRUITING

Mountain View, California, 94040, United States

Contact Email: •••••@•••••
OFTALMIKA Sp. z o.o
RECRUITING

Bydgoszcz, Poland

Contact Email: •••••@•••••
Oculomedica Sp. z o.o.
RECRUITING

Bydgoszcz, Poland

Contact Email: •••••@•••••
Oftalmocentrum Betliarska
RECRUITING

Bratislava, Slovakia

Contact Email: •••••@•••••
Piedmont Eye Center
RECRUITING

Lynchburg, Virginia, 24502, United States

Contact Email: •••••@•••••
Piedmont Retina Specialists, P.A. - Winston-Salem Office
RECRUITING

Winston-Salem, North Carolina, 27103, United States

Contact Email: •••••@•••••
Rabin Medical Center
RECRUITING

Petah Tikva, Israel

Contact Email: •••••@•••••
Rambam Health Care Campus (RHCC)
RECRUITING

Haifa, Israel

Contact Email: •••••@•••••
Red River Research Partners
RECRUITING

Plainfield, Illinois, 60586, United States

Contact Email: •••••@•••••
Retina Associates of Michigan
RECRUITING

Grand Blanc, Michigan, 48439, United States

Contact Email: •••••@•••••
Retina Associates of Utah
RECRUITING

Salt Lake City, Utah, 84107, United States

Contact Email: •••••@•••••
Retina Associates of Western New York
RECRUITING

Rochester, New York, 14620, United States

Contact Email: •••••@•••••
Retina Consultants of Carolina P.A
RECRUITING

Greenville, South Carolina, 29605, United States

Contact Email: •••••@•••••
Retina Consultants of Hawaii
RECRUITING

‘Aiea, Hawaii, 96701, United States

Contact Email: •••••@•••••
Retina Consultants of San Diego
RECRUITING

Poway, California, 92064, United States

Contact Email: •••••@•••••
Retina Consultants of Southern Colorado
RECRUITING

Colorado Springs, Colorado, 80909, United States

Contact Email: •••••@•••••
Retina Consultants of Texas
RECRUITING

Katy, Texas, 77494, United States

Contact Email: •••••@•••••
Retina Consultants of Texas
RECRUITING

Schertz, Texas, 78154, United States

Contact Email: •••••@•••••
Retina Group of Washington
RECRUITING

Chevy Chase, Maryland, 20815, United States

Contact Email: •••••@•••••
Retina Research Institute of Texas Integrated Clinical Research
RECRUITING

Abilene, Texas, 79606, United States

Contact Email: •••••@•••••
Retina Specialists - Towson
RECRUITING

Towson, Maryland, 21204, United States
Retina Specialists of Tampa
RECRUITING

Wesley Chapel, Florida, 33544, United States

Contact Email: •••••@•••••
Retina Vitreous Associates of Florida - Saint Petersburg
RECRUITING

St. Petersburg, Florida, 33711, United States

Contact Email: •••••@•••••
Retinal Consultants Medical Group
RECRUITING

Sacramento, California, 95841, United States

Contact Email: •••••@•••••
Retinal Consultants Medical Group - Parkcenter Drive
RECRUITING

Sacramento, California, 95825, United States

Contact Email: •••••@•••••
Salt Lake Retina
RECRUITING

West Jordan, Utah, 84088, United States

Contact Email: •••••@•••••
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie
RECRUITING

Lublin, Poland

Contact Email: •••••@•••••
Shamir Medical Center Ophthalmology Out Patient Clinic
RECRUITING

Be’er Ya‘aqov, Israel

Contact Email: •••••@•••••
Sierra Eye Associates
RECRUITING

Reno, Nevada, 89502, United States

Contact Email: •••••@•••••
Southern Vitreoretinal Associates
RECRUITING

Tallahassee, Florida, 32308, United States

Contact Email: •••••@•••••
Tennessee Retina
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Email: •••••@•••••
Texas Retina Associates
RECRUITING

Dallas, Texas, 75231, United States

Contact Email: •••••@•••••
Texas Retina Associates
RECRUITING

Plano, Texas, 75075, United States

Contact Email: •••••@•••••
The Retina Partners
RECRUITING

Encino, California, 91436, United States

Contact Email: •••••@•••••
The Tel-Aviv Sourasky Medical Centre
RECRUITING

Tel Aviv, Israel

Contact Email: •••••@•••••
Tulsa Retina Consultant
RECRUITING

Tulsa, Oklahoma, 74114, United States

Contact Email: •••••@•••••
Tyler Retina Consultants
RECRUITING

Tyler, Texas, 75703, United States

Contact Email: •••••@•••••
Universitatsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, Germany

Contact Email: •••••@•••••
VRCNY/Long Island Vitreoretinal Consultants
RECRUITING

Westbury, New York, 11590, United States

Contact Email: •••••@•••••
Virginia Retina Center
RECRUITING

Warrenton, Virginia, 20186, United States

Contact Email: •••••@•••••
Warszawski Szpital Okulistyczny
RECRUITING

Warsaw, Poland

Contact Email: •••••@•••••

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