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Brain scans could reveal hidden stroke risk in artery disease patients

NCT ID NCT05907629

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks at whether special MRI scans can help predict which people with severe narrowing of brain arteries (70-99% stenosis) are most likely to have another stroke. Participants have already had a minor stroke and are enrolled in a larger treatment trial. They will get an extra MRI at the start and after one year. The goal is to find imaging markers that could guide future treatments and improve care for this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify MRI markers that predict which patients with severe intracranial artery narrowing are at highest risk of another stroke, enabling more targeted treatments.
What could go wrong
This is an observational imaging study, not a treatment trial. The MRI biomarkers may not reliably predict stroke risk, and results may not change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

ICAS patients who have a recent stroke and was enrolled into CAPTIVA.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA * Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen Exclusion Criteria: * Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62 * Gadolinium contrast allergy or acute or chronic kidney disease with eGFR\<30 ml/min/1.73m2

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Conditions

The condition(s) this trial relates to.

cerebral artery stenosis intracranial arteriosclerosis ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracranial atherosclerotic stenosis (ICAS) Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    28 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baptist Medical Center Jacksonville

    RECRUITING

    Jacksonville, Florida, 32207, United States

  • Barnes Jewish Hospital

    RECRUITING

    St Louis, Missouri, 63108, United States

  • Buffalo General Medical Center

    RECRUITING

    Buffalo, New York, 14203, United States

  • Carolinas Medical Center

    NOT_YET_RECRUITING

    Charlotte, North Carolina, 28203, United States

  • Cleveland Clinic Akron General

    NOT_YET_RECRUITING

    Akron, Ohio, 44307, United States

  • Cleveland Clinic Tradition Hospital

    NOT_YET_RECRUITING

    Port Saint Lucie, Florida, 34987, United States

  • Covenant Medical Center

    NOT_YET_RECRUITING

    Lubbock, Texas, 79410, United States

  • Duke University Hospital

    NOT_YET_RECRUITING

    Durham, North Carolina, 27705, United States

  • Hartford Hospital

    NOT_YET_RECRUITING

    Hartford, Connecticut, 06106, United States

  • Jackson Memorial Hospital, Miami

    RECRUITING

    Miami, Florida, 33136, United States

  • M Health Fairview University of Minnesota Medical Center

    NOT_YET_RECRUITING

    Minneapolis, Minnesota, 55455, United States

  • MedStar Washington Hospital Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Memorial Hermann Texas Medical Center

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

  • Mercy St. Vincent Medical Center

    NOT_YET_RECRUITING

    Toledo, Ohio, 43608, United States

  • Metro Health Hospital

    NOT_YET_RECRUITING

    Wyoming, Michigan, 49519, United States

  • NYP Columbia University Medical Center

    NOT_YET_RECRUITING

    New York, New York, 10032, United States

  • North Shore University Hospita

    RECRUITING

    Manhasset, New York, 11030, United States

  • Prisma Health Richland Hospital

    NOT_YET_RECRUITING

    Columbia, South Carolina, 29203, United States

  • SIH Memorial Hospital of Carbondale

    NOT_YET_RECRUITING

    Carbondale, Illinois, 62901, United States

  • UH Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • UVA Medical Center

    RECRUITING

    Charlottesville, Virginia, 22908, United States

  • University of Alabama Hospital

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Chicago Medical Center

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Cincinnati Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • University of Colorado Hospital

    NOT_YET_RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Illinois Hospital

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Texas Medical Branch

    RECRUITING

    Galveston, Texas, 77555, United States

  • Yale New Haven Hospital

    RECRUITING

    New Haven, Connecticut, 06510, United States

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