Could a double-barrel cholesterol drug shrink artery plaque better than statins alone?
NCT ID NCT07036991
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This study compares two approaches for people with mild-to-moderate carotid artery stenosis (narrowing of the neck arteries): a standard statin regimen versus a statin plus a PCSK9 inhibitor (evolocumab) given as biweekly injections. The main goal is to see whether the combination reduces plaque buildup more effectively over six months. Participants are adults who do not need surgery and have at least 30% plaque burden on ultrasound.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Evolocumab (biweekly injections) plus rosuvastatin or atorvastatin, with or without ezetimibe
- What this could lead to
- If it works, this could point toward a more effective way to shrink artery plaque and lower stroke risk in people with carotid artery stenosis.
- What could go wrong
- This is an observational study, not a randomized trial, so results may be less definitive. The added drug also requires regular injections and may cause side effects like muscle pain or liver issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Changhai Hospital
RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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