Brain injury study seeks clues to thinking decline

NCT ID NCT06480838

Recruiting now Knowledge-focused Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury. The goal is to better understand how blood vessel damage contributes to long-term brain health and to inform future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If links between early blood flow problems and later thinking difficulties are found, this could point toward new ways to protect the brain after injury.
What could go wrong: This is an observational study, not a treatment test. It may not prove cause and effect, and results might not apply to all types of brain injury.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic transient ischemic attack traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN INJURY TRAUMATIC MODERATE BRAIN INJURY TRAUMATIC SEVERE TBI TBI (TRAUMATIC BRAIN INJURY) TRAUMATIC BRAIN INJURY WITH LOSS OF CONSCIOUSNESS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Parkland Health and Hospital System
RECRUITING

Dallas, Texas, 75235, United States
Texas Health Presbyterian Hospital
RECRUITING

Dallas, Texas, 75231, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

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