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Sleep drug may boost PTSD therapy in veterans

NCT ID NCT07686731

Not yet recruiting Symptom relief Sponsor: Northern California Institute of Research and Education Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether adding the sleep medication suvorexant to a shortened form of exposure therapy helps veterans with PTSD and insomnia. Participants take suvorexant or a placebo nightly for 8 weeks while attending weekly therapy sessions. Researchers measure changes in PTSD symptoms, sleep quality, and overall functioning to see if the combination works better than therapy alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Suvorexant
What this could lead to
If it works, this could point toward a more effective treatment for PTSD and insomnia in veterans, potentially improving both mental health and daily functioning.
What could go wrong
This is a Phase 4 trial, but results may not apply to all veterans. Suvorexant can cause side effects like drowsiness or dizziness, and the therapy may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic combat disorder insomnia post-traumatic stress disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSOMNIA PTSD - POST TRAUMATIC STRESS DISORDER TBI (TRAUMATIC BRAIN INJURY)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • San Francisco VA Health Care System

    San Francisco, California, 94121-1545, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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