TBI (TRAUMATIC BRAIN INJURY)

This study tests whether giving a continuous infusion of concentrated salt water (hypertonic saline) early after severe traumatic brain injury can improve survival and daily living independence at 6 months. About 760 patients with a low Glasgow Coma Scale score and high risk of b…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study tests a virtual cognitive rehabilitation program designed for refugees and asylum seekers who have had a traumatic brain injury (TBI) and struggle with thinking and memory. The program includes 8 virtual sessions led by trained bilingual staff, covering brain injury ed…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study is testing whether hyperbaric oxygen therapy (HBOT) can improve thinking, mood, and quality of life in veterans who have traumatic brain injury, PTSD, anxiety, or depression. Fifty-four veterans will receive multiple HBOT sessions in a pressurized chamber while breathi…

This study explores whether two computer-based tasks can measure decision-making fatigue in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will compare results from TBI patients with those from healthy volunteers to see if the tasks are practical…

This study looks at whether a new blood test can help emergency room doctors better assess patients with mild traumatic brain injury (TBI). The test checks for brain injury markers in the blood and may reduce the need for CT scans. Researchers will study how well the test works i…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study follows 100 adults who had a traumatic brain injury and completed 60 sessions of hyperbaric oxygen therapy. Researchers will test their thinking, memory, and quality of life 1 to 4 years later to see if improvements stick. The goal is to understand the long-term effect…

This study looks at how a concussion (mild traumatic brain injury) before age 6 might change brain structure and behavior. Researchers will use MRI scans to compare 30 children who had a concussion with 30 children who had a limb injury. The goal is to better understand the short…

This study is testing whether a special electrode placed deep in the brain can detect abnormal electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury. These waves may cause further damage. The study will involve 15 people who already need…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…