TBI (TRAUMATIC BRAIN INJURY)

This study tests whether giving a concentrated salt solution (hypertonic saline) early after a severe traumatic brain injury can help more people survive and regain independence in daily activities. About 760 patients in intensive care will receive either the salt solution or sta…

This study looks at a new blood test that can quickly tell if a person with a mild head injury has brain damage. The goal is to see if using this test in the emergency room can reduce the number of unnecessary CT scans, speed up care, and help doctors make better decisions. The s…

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for ICU patients with traumatic brain injury. Researchers will check if it reduces inflammation in the blood and affects vital signs like blood pressure and brain pressure. T…

This study tests whether a safe, non-invasive brain stimulation technique called TACS can improve thinking and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults to see if the approach is practical and well-to…

This study tests a program designed to help improve thinking and memory in refugees and asylum seekers who have had a traumatic brain injury (TBI). Researchers want to see if the program is practical and well-liked. About 50 people will be split into two groups: one starts the pr…

This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, memory, and mental health in veterans with traumatic brain injury, PTSD, or post-concussion syndrome. Researchers will measure changes in PTSD symptoms, depre…

This study looks at people who had a traumatic brain injury and completed hyperbaric oxygen therapy (HBOT) 1 to 4 years ago. Researchers want to see if the thinking improvements from HBOT are still there. About 100 adults will take computer tests and answer questionnaires about m…

This study looks at whether cognitive remediation—a type of brain training with coaching—can improve thinking skills, daily function, and behavior in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take …

This study looks at how a concussion before age 6 might change a child's brain and behavior. Researchers will use brain imaging to compare 30 children with a concussion to 30 children with a broken arm or leg. The goal is to better understand the short- and long-term effects of m…

This study watches how different types of anesthesia change blood flow and oxygen use in the brains of children having an MRI. Up to 1,000 kids from birth to 18 years old will take part. The goal is to learn more, not to test a new treatment.

This study is testing whether a special electrode placed deep in the brain can detect harmful electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury (TBI). These waves are linked to worse outcomes, but are hard to spot with standard monit…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications from the body too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection.…