Salt water infusion could boost brain injury recovery

NCT ID NCT07319208

Recruiting now Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tests whether giving a continuous infusion of concentrated salt water (hypertonic saline) early after severe traumatic brain injury can improve survival and daily living independence at 6 months. About 760 patients with a low Glasgow Coma Scale score and high risk of brain swelling will receive the infusion for 48 hours. The goal is to reduce pressure inside the skull and protect the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hypertonic saline solution (concentrated salt water)
What this could lead to: If it works, this could offer a simple, widely available treatment to help more people survive traumatic brain injury and regain independence.
What could go wrong: This is a large phase 3 trial, but the treatment is only for a specific high-risk group and may not improve outcomes for all. Side effects like high sodium or chloride levels need careful monitoring.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TBI (TRAUMATIC BRAIN INJURY)

Contacts and locations

Locations

AP-HM
NOT_YET_RECRUITING

Marseille, France
CH de Annecy Genevois
NOT_YET_RECRUITING

Épagny, France
CHRU de Tours
NOT_YET_RECRUITING

Tours, France
CHU Caen Normandie
RECRUITING

Caen, France
CHU Henri Mondor APHP
RECRUITING

Créteil, France
CHU Lariboisière, AP-HP
NOT_YET_RECRUITING

Paris, France
CHU d'Angers
NOT_YET_RECRUITING

Angers, France
CHU de Brest
RECRUITING

Brest, France
CHU de Clermont- Ferrand
RECRUITING

Clermont-Ferrand, France
CHU de Grenoble
NOT_YET_RECRUITING

Grenoble, France
CHU de Lille
RECRUITING

Lille, France
CHU de Nancy
NOT_YET_RECRUITING

Nancy, France
CHU de Nantes
RECRUITING

Nantes, France
CHU de Nice
RECRUITING

Nice, France
CHU de Poitiers
NOT_YET_RECRUITING

Poitiers, France
CHU de Rennes
RECRUITING

Rennes, France
CHU de Rouen
NOT_YET_RECRUITING

Rouen, France
CHU de St- Etienne
NOT_YET_RECRUITING

Saint-Etienne, France
CHU de Strasbourg
NOT_YET_RECRUITING

Strasbourg, France
CHU de Toulouse
RECRUITING

Toulouse, France
GHU Paris Cité
NOT_YET_RECRUITING

Paris, France
HCL
NOT_YET_RECRUITING

Lyon, France
Hôpital BEAUJON APHP
RECRUITING

Clichy, France

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