Salt water infusion could boost brain injury recovery

NCT ID NCT07319208

Recruiting now Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a continuous infusion of concentrated salt water (hypertonic saline) early after severe traumatic brain injury can improve survival and daily living independence at 6 months. About 760 patients with a low Glasgow Coma Scale score and high risk of brain swelling will receive the infusion for 48 hours. The goal is to reduce pressure inside the skull and protect the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

hypertonic saline solution (concentrated salt water)

What this could lead to

If it works, this could offer a simple, widely available treatment to help more people survive traumatic brain injury and regain independence.

What could go wrong

This is a large phase 3 trial, but the treatment is only for a specific high-risk group and may not improve outcomes for all. Side effects like high sodium or chloride levels need careful monitoring.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TBI TRAUMATIC BRAIN INJURY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AP-HM
NOT_YET_RECRUITING

Marseille, France

Contact Email: •••••@•••••
CH de Annecy Genevois
NOT_YET_RECRUITING

Épagny, France

Contact Email: •••••@•••••
CHRU de Tours
NOT_YET_RECRUITING

Tours, France

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CHU Caen Normandie
NOT_YET_RECRUITING

Caen, France

Contact Email: •••••@•••••
CHU Henri Mondor APHP
NOT_YET_RECRUITING

Créteil, France

Contact Email: •••••@•••••
CHU Lariboisière, AP-HP
NOT_YET_RECRUITING

Paris, France

Contact Email: •••••@•••••
CHU d'Angers
NOT_YET_RECRUITING

Angers, France

Contact Email: •••••@•••••
CHU de Brest
NOT_YET_RECRUITING

Brest, France

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CHU de Clermont- Ferrand
NOT_YET_RECRUITING

Clermont-Ferrand, France

Contact Email: •••••@•••••

Contact Email: •••••@•••••
CHU de Grenoble
NOT_YET_RECRUITING

Grenoble, France

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CHU de Lille
NOT_YET_RECRUITING

Lille, France

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CHU de Nancy
NOT_YET_RECRUITING

Nancy, France

Contact Email: •••••@•••••
CHU de Nantes
RECRUITING

Nantes, France

Contact Phone: •••-•••-•••• Email: •••••@•••••
CHU de Nice
NOT_YET_RECRUITING

Nice, France

Contact Email: •••••@•••••
CHU de Poitiers
NOT_YET_RECRUITING

Poitiers, France

Contact Email: •••••@•••••
CHU de Rennes
NOT_YET_RECRUITING

Rennes, France

Contact Email: •••••@•••••
CHU de Rouen
NOT_YET_RECRUITING

Rouen, France

Contact Email: •••••@•••••
CHU de St- Etienne
NOT_YET_RECRUITING

Saint-Etienne, France

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CHU de Strasbourg
NOT_YET_RECRUITING

Strasbourg, France

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CHU de Toulouse
NOT_YET_RECRUITING

Toulouse, France

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GHU Paris Cité
NOT_YET_RECRUITING

Paris, France

Contact Email: •••••@•••••
HCL
NOT_YET_RECRUITING

Lyon, France

Contact Email: •••••@•••••
Hôpital BEAUJON APHP
NOT_YET_RECRUITING

Clichy, France

Contact Email: •••••@•••••