Can a Cholesterol-Lowering shot reverse brain artery blockages?
NCT ID NCT06902740
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 weeks. The main goal is to see if plaque burden decreases on MRI scans, which could lower future stroke risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Recaticimab (a PCSK9 inhibitor) combined with statin (rosuvastatin or atorvastatin)
What this could lead to
If successful, this could show that adding a PCSK9 inhibitor to statins reverses artery plaque in the brain, potentially reducing stroke risk.
What could go wrong
This is a Phase 4 trial with 300 participants, but it is open-label (not blinded for patients) and uses imaging endpoints rather than clinical outcomes like stroke reduction. Results may not translate to fewer strokes.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INTRACRANIAL ATHEROSCLEROSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Baotou Central Hospital
NOT_YET_RECRUITINGBaotou, Inner Mongolia, 014000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
NOT_YET_RECRUITINGCangzhou, Hebei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Chinese PLA General Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100853, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Chongqing General Hospital
NOT_YET_RECRUITINGChongqing, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITINGHarbin, Heilongjiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Hebei Provincial People's Hospital
RECRUITINGShijiazhuang, Hebei, 050051, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Huashan Hospital, Fudan University
NOT_YET_RECRUITINGShanghai, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Jining First People's Hospital
NOT_YET_RECRUITINGJining, Shandong, 272000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Liaocheng People's Hospital
NOT_YET_RECRUITINGLiaocheng, Shandong, 252000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Nanjing First Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, 210000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
RECRUITINGBeijing, Beijing Municipality, 100730, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Peking University Third Hospital Qinhuangdao Hospital
NOT_YET_RECRUITINGQinhuangdao, Hebei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Taihe Hospital
NOT_YET_RECRUITINGShiyan, Hubei, 442000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Tangshan Worker's Hospital
NOT_YET_RECRUITINGTangshan, Hebei, 063000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITINGQingdao, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
The Third Affiliated Hospital of Sun Yat-sen University, Yuedong Hospital
NOT_YET_RECRUITINGMeizhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
The first affiliated hospital of zhengzhou university
NOT_YET_RECRUITINGZhengzhou, Henan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Weifang People's Hospital
NOT_YET_RECRUITINGWeifang, Shandong, 261000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, Hubei, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact