Can a Cholesterol-Lowering shot reverse brain artery blockages?
NCT ID NCT06902740
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 weeks. The main goal is to see if plaque burden decreases on MRI scans, which could lower future stroke risk.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Recaticimab (a PCSK9 inhibitor) combined with statin (rosuvastatin or atorvastatin)
- What this could lead to
- If successful, this could show that adding a PCSK9 inhibitor to statins reverses artery plaque in the brain, potentially reducing stroke risk.
- What could go wrong
- This is a Phase 4 trial with 300 participants, but it is open-label (not blinded for patients) and uses imaging endpoints rather than clinical outcomes like stroke reduction. Results may not translate to fewer strokes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Baotou Central Hospital
NOT_YET_RECRUITINGBaotou, Inner Mongolia, 014000, China
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Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine
NOT_YET_RECRUITINGCangzhou, Hebei, China
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Chinese PLA General Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100853, China
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Chongqing General Hospital
NOT_YET_RECRUITINGChongqing, China
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First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITINGHarbin, Heilongjiang, China
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Hebei Provincial People's Hospital
RECRUITINGShijiazhuang, Hebei, 050051, China
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Huashan Hospital, Fudan University
NOT_YET_RECRUITINGShanghai, China
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Jining First People's Hospital
NOT_YET_RECRUITINGJining, Shandong, 272000, China
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Liaocheng People's Hospital
NOT_YET_RECRUITINGLiaocheng, Shandong, 252000, China
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Nanjing First Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, 210000, China
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Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
RECRUITINGBeijing, Beijing Municipality, 100730, China
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Peking University Third Hospital Qinhuangdao Hospital
NOT_YET_RECRUITINGQinhuangdao, Hebei, China
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Taihe Hospital
NOT_YET_RECRUITINGShiyan, Hubei, 442000, China
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Tangshan Worker's Hospital
NOT_YET_RECRUITINGTangshan, Hebei, 063000, China
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The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITINGQingdao, Shandong, China
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The Third Affiliated Hospital of Sun Yat-sen University, Yuedong Hospital
NOT_YET_RECRUITINGMeizhou, Guangdong, China
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The first affiliated hospital of zhengzhou university
NOT_YET_RECRUITINGZhengzhou, Henan, China
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Weifang People's Hospital
NOT_YET_RECRUITINGWeifang, Shandong, 261000, China
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Zhongnan Hospital of Wuhan University
NOT_YET_RECRUITINGWuhan, Hubei, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Cholesterol control may cut stroke risk in brain artery disease
- New MRI technique could help predict strokes in High-Risk patients
- New drug combo aims to stop repeat strokes in High-Risk patients
- Could a single shot boost stroke recovery? new trial aims to find out
- Brain stent blood thinner study pulled before it began
- New brain stent aims to stop strokes in High-Risk patients