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Could a pill calm Post-Stroke muscle spasms? new trial investigates

NCT ID NCT07704840

Not yet recruiting Symptom relief Sponsor: Alberto Esquenazi Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether an oral drug called BMS-986368 can reduce spasticity—muscle tightness and spasms—in adults who had a stroke 4 to 18 months ago. The drug works by boosting natural compounds in the body that calm overactive nerves. Researchers will measure changes in muscle stiffness and arm function, and monitor safety, comparing the drug against a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an experimental drug called BMS-986368, a FAAH/MAGL inhibitor that increases natural calming compounds in the body
What this could lead to
If it works, this could offer a new oral treatment option for people with persistent muscle stiffness after a stroke.
What could go wrong
This is an early pilot study with only 42 participants, so results may not apply broadly. The drug may not prove effective or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Muscle Spasticity nervous system disorder stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-STROKE SPASTICITY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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