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Magnetic pulses may unlock secrets of language after stroke

NCT ID NCT05425615

Knowledge-focused Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study uses transcranial magnetic stimulation (TMS) to investigate how the brain processes language in people who have had a stroke and developed aphasia, as well as in healthy volunteers. Participants receive targeted magnetic pulses to specific brain areas while performing language tasks. The goal is to measure changes in reaction time and accuracy, shedding light on the brain's language networks and potential pathways for recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial Magnetic Stimulation (TMS)
What this could lead to
If successful, this research could reveal how TMS affects language recovery after stroke, potentially guiding future therapies for aphasia.
What could go wrong
This is an early-stage, exploratory study focused on understanding brain processes, not a treatment trial. Results may not directly translate into clinical benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 135 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jun 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with left hemisphere stroke * Consent date \>= 1 month after stroke onset * Right-handed * Fluent in English * 18 years of age or older Exclusion Criteria: * Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing * Non-decisional per decisionality questionnaire or other clinical assessment * Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease) * A chronic medical condition that is not treated or is unstable * Presence of 1. cardiac stimulators or pacemakers or intracardiac lines 2. neurostimulators 3. medication infusion device 4. any other implants near the scalp (e.g., cochlear implants) or in the eye 5. metal in the body * Pregnancy * History of skull fractures, or skin diseases * History of ongoing or unmanaged seizures or a family history of epilepsy * Presence of factors that potentially decrease seizure thresholds * On pro-convulsant medications * Untreated Sleep deprivation or insomnia * Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users) * History of dyslexia or other developmental learning disabilities

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Conditions

The condition(s) this trial relates to.

aphasia Language language disorder specific language impairment stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aphasia Language Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

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