Language disorder

This trial tests whether combining aerobic exercise with a targeted reading therapy, called Phono-Motor Therapy, can improve reading skills in people who have reading difficulties after a stroke. Participants will receive both interventions, and researchers will measure changes i…

This trial tests whether adding metacognitive training—exercises that help people think about their own thinking—to standard word-finding rehabilitation can improve language skills in people with chronic aphasia after a stroke. The study involves 18 participants who will receive …

This trial investigates an unapproved medical device designed to help control a specific disease. Participants receive the device to see if it can reduce symptoms or manage the condition. The study focuses on safety and effectiveness in people with the disease.

This trial investigates whether a non-invasive brain stimulation technique called tACS, applied during speech therapy, can help people recover language abilities after a stroke. The study includes 120 adults who have had a left-hemisphere stroke and experience aphasia (difficulty…

This study is testing whether a cochlear implant is safe and effective for infants and toddlers who are deaf in one ear. Sixty children will receive the implant and be followed until age 5. Researchers will compare their hearing abilities to children with normal hearing and to th…

This study tests whether adding extra supports—like telehealth coaching and practical help—to a group parenting program can prevent language delays in young children (12-42 months) of parents with substance use disorders. 244 parents will be assigned to the group program alone or…

This trial tests a structured, 8-session program designed to help adults who stutter feel less anxious and more confident in job interviews. The program uses techniques like cognitive restructuring, voluntary stuttering, and simulated interviews to gradually reduce fear of negati…

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This pilot study tests whether repeated transcranial magnetic stimulation (rTMS) can reduce stuttering in adults. Two participants will receive 10 rTMS sessions, and researchers will measure changes in brain activity and speech. The goal is to see if this non-invasive treatment c…

This study tests a smartwatch-based program designed to help people with post-stroke aphasia—a condition that impairs language—improve their ability to name objects. Over six weeks, participants receive daily prompts to name pictures and answer simple yes/no questions about the i…

This phase 2 trial is testing whether the drug lumateperone can reduce stuttering symptoms in adults with moderate to severe childhood-onset stuttering. Participants take either lumateperone (21 mg or 42 mg) or a placebo daily for several weeks. Researchers will measure changes i…

This trial tests whether six months of group singing can improve mood, quality of life, and language recovery in stroke survivors with aphasia, while also supporting their personal caregivers. Half of the participants will attend weekly singing sessions; the other half will recei…

This study tests whether a gentle, non-invasive brain stimulation technique called tDCS can help people recover language abilities after a stroke that causes aphasia. Participants receive 14 sessions of tDCS over 7 days combined with speech therapy. Researchers measure language i…

This study compares word learning in late-talking toddlers (ages 2–3) who receive a behavioral treatment called VAULT. One group is taught words from categories they already know (like animals), while the other group learns words from less familiar categories. The goal is to see …

This study tests whether a precise form of brain stimulation (TMS) combined with language therapy can improve word-finding in people who have aphasia after a stroke. Fifty stroke survivors will receive either targeted or control stimulation during therapy sessions. The goal is to…

This study tests whether combining home-based brain stimulation (tDCS) with virtual speech therapy can improve communication in adults with primary progressive aphasia, a language disorder often caused by Alzheimer's disease. Eighty participants will receive either active or plac…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This study tests a speech therapy program for bilingual Spanish-English or Spanish-Catalan speakers with primary progressive aphasia, a condition that slowly damages language abilities. Sixty participants will receive personalized script training via video sessions, while 30 othe…

This study tests an educational support group program for people with progressive aphasia (a language disorder caused by Alzheimer's or other dementias) and their carepartners. The program includes group education, support sessions, and communication skills training. Researchers …

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study tests whether combining a gentle, non-invasive brain stimulation technique called rTMS with personalized language training can improve language skills in children aged 2 to 5 with global developmental delay. About 50 children will be split into two groups: one gets bot…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve word-finding in people who have trouble speaking after a stroke. Researchers will use MRI scans to guide the stimulation and see how the brain responds. The trial involves 45 participants …

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking or understanding language) after a stroke. About 50 adults who had a stroke at least six months ago will receive eith…

This study tests if a digital app called LEXURE can improve language skills in people who have trouble speaking after a stroke (aphasia). About 116 adults who had a stroke at least 3 months ago will either use the app or do workbook exercises. The goal is to see if the app helps …

This study is testing whether a liquid form of leucovorin (a type of folate) can improve social communication and language in young children with autism. Researchers will enroll 80 children ages 2.5 to 5 years who have a specific antibody linked to folate transport. The study las…

This study tests a new speech therapy technique for people with aphasia (trouble speaking) after a stroke. Instead of copying a therapist's voice, participants will practice speaking along with an AI-cloned version of their own voice. The goal is to see if this personalized appro…

This study tests a personalized, virtual speech therapy program for people with primary progressive aphasia (a type of dementia that affects language) and their communication partners. The goal is to see if the program improves communication and quality of life. About 30 particip…

This study is testing whether a 10-week music-based program done at home on a tablet can help people recover from a stroke. The program includes rhythm exercises, singing, playing a xylophone, and listening to music. Researchers will compare 100 stroke survivors who do the music …

This study tests whether a safe, noninvasive brain stimulation technique called HD-tDCS can reduce stuttering symptoms like repetitions and blocks. Fifty adults who stutter will receive a single session of stimulation and complete speaking tasks before and after. The goal is to s…

This study tests three different naming treatments for people with aphasia, a language disorder often caused by stroke. The goal is to see which approach best helps participants remember words and use them in daily life. Thirty adults with chronic aphasia will practice naming pic…

This study tests whether a safe, non-invasive brain stimulation technique called theta burst stimulation (TBS) can boost language recovery in people with post-stroke aphasia. 45 adults with non-fluent aphasia will receive either real TBS (targeting the left or right brain) or a s…

This study is testing a non-invasive brain stimulation technique called temporal interference stimulation to see if it can safely improve language abilities in people with post-stroke aphasia. The trial will enroll 40 adults who have language problems after a stroke. Researchers …

This study tests whether a mild electrical current applied to the back of the brain (cerebellar tDCS) can boost language therapy for people who have trouble finding words after a stroke. Sixty adults who had a left-hemisphere stroke at least six months ago and still have aphasia …

This study tests whether a 12-week high-intensity exercise program can improve language, thinking, and physical health in 120 adults with aphasia (trouble speaking or understanding language) after a stroke. Participants are randomly assigned to either high-intensity or low-intens…

This study tests whether adding hand gestures to standard speech therapy helps Cantonese speakers with aphasia find words more easily. 90 participants will first receive verbal-only therapy, then after a break, switch to therapy that combines gestures with speech. Researchers wil…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy can improve language in people with mild aphasia after a stroke. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along with 10 day…

This study tests whether a gentle electrical current applied to the brain (tACS) during language therapy can help people with post-stroke aphasia name objects more accurately. 64 adults with aphasia will receive either real or sham stimulation while practicing word-naming tasks. …

This study tests whether joining a community choir for 12 weeks can improve communication and quality of life for people with chronic aphasia (trouble speaking or understanding language) after a stroke. Fifty participants will be randomly assigned to either choir sessions plus ho…

This study tests a smartphone app called Zenicom that provides personalized speech therapy exercises for people who have trouble speaking after a stroke (aphasia). Twenty adults with recent stroke and aphasia will either receive standard speech therapy alone or standard therapy p…

This study tests whether adjusting the timing of speech therapy sessions can help people with aphasia (trouble speaking after a stroke) remember words better and use them in daily life. About 32 adults with chronic aphasia will practice naming pictures using a computer program th…

This pilot study tests whether a non-invasive device that stimulates the vagus nerve through the ear can help people with chronic aphasia (trouble finding words) after a stroke. Thirty-six participants will use the device at home while doing computer-based speech therapy for six …

This small pilot study tests whether a brain-computer interface combined with electrical stimulation can improve swallowing difficulties and language problems in people who had a stroke at least three months ago. Ten participants will use the device for hand rehabilitation while …

This study tests whether a speech therapy that involves parents can improve early social and communication skills in children aged 6 months to 5 years with neurodevelopmental disabilities. One group gets the parent-focused therapy, while the other gets standard speech therapy. Re…

This study tests whether a gentle brain stimulation technique (tDCS) combined with standard speech therapy can reduce stuttering severity and its negative impact on daily life. Sixteen adults who stutter will receive both treatments, and researchers will measure changes in speech…

This study tests whether a technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who had a traumatic brain injury at least a year ago. The device delivers a very low electrical current through electrodes…

This study tests a new approach to help children ages 7 to 11 who have trouble saying the /s/ sound (like in "snake"). Participants will do very short 10-minute speech lessons over video chat four times a week for eight weeks. The goal is to see if these brief, frequent sessions …

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This study tests whether a gentle, noninvasive electrical current applied to the scalp can improve speech fluency in adults who stutter. Researchers will give 80 participants three sessions of brain stimulation while they read aloud, then measure changes in brain activity and stu…

This study tests whether a gentle electrical current applied to the front of the brain (tDCS) can reduce fatigue and improve language and attention in people who have had a stroke. Sixty participants will receive either real or fake tDCS during 10 sessions of speech therapy. The …

This study tests whether showing an aphasia identification card helps healthy volunteers better understand a person with aphasia. 160 service workers will listen to sentences from a speaker with aphasia, with or without seeing the card first. Researchers will measure comprehensio…

This study explores whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can help improve language recovery in people who have lost speech abilities after a stroke. Researchers will also test the same stimulation in…

This study looks at how the brain processes auditory feedback during speech in people with aphasia, a communication disorder often caused by stroke. Researchers will test 50 adults with aphasia and 50 healthy adults using speech tasks, EEG, and fMRI. The goal is to find brain mar…

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This study uses transcranial magnetic stimulation (TMS) to investigate how the brain processes language in people who have had a stroke and developed aphasia, as well as in healthy volunteers. Participants receive targeted magnetic pulses to specific brain areas while performing …

This study looks at how genes and brain scans can help predict recovery from aphasia, a language disorder that often follows a stroke. Researchers will enroll 90 adults aged 40-90 who have had a stroke and have trouble speaking or understanding language. By understanding these bi…

This study records brain activity from epilepsy patients who already have electrodes implanted for medical reasons. While listening to sentences and stories, their neural signals are analyzed to map how the brain processes language. The goal is to understand the brain's language …

This study uses brain scans (fMRI) to compare brain activity when adults who stutter produce stuttered versus non-stuttered speech. Researchers aim to understand which brain circuits are involved. Fifty adults aged 18-65 who stutter will participate. This is not a treatment study…

This study collects medical information and samples from people with hearing, balance, taste, smell, voice, speech, or language disorders. Researchers aim to use this data for future studies and to find candidates for other research. Participants receive standard care, and no exp…

This study looks at how 8-month-old babies' brains process speech sounds, using a non-invasive EEG cap. Researchers want to see if differences in brain activity can predict language skills at 18 months, especially in infants with a family history of language or learning disorders…

This study follows 120 children aged 3-6 who stutter or have typical speech, to learn why some recover naturally. Kids complete speech tests, wear brain-monitoring caps, and speak in virtual reality classrooms. Researchers track brain activity, heart rate, and skin responses to f…

This study aims to develop and test a new scale that measures how well people with aphasia communicate in everyday life, not just in lab tasks. Researchers will enroll 50 Italian-speaking adults with language disorders after a stroke. The goal is to create a tool that considers g…

This study tests whether speech therapy delivered via video call works as well as traditional in-clinic therapy for people with aphasia, a language disorder caused by stroke. One hundred adults who had a stroke at least a year ago will receive either remote or in-person therapy. …

This study looks at language difficulties in people with psychosis, including those at risk, experiencing a first episode, or diagnosed with schizophrenia. Researchers will give a full language test to 90 patients and compare results with a healthy control group. The goal is to b…

This study tests whether teaching parents to talk more with their babies during regular well-child visits can improve language development. Researchers will enroll 400 parent-child pairs and compare those who receive the 'Talk With Me Baby' coaching to those who get standard care…

This study looks at how the brain makes sense of sentences. Researchers will record brain activity from electrodes already placed in the brains of people with epilepsy for medical reasons. Participants read or listen to sentences word by word and pick a picture that matches. In s…

This study investigates whether brain surface recordings can decode Mandarin Chinese speech, including tones, from imagined speech. About 50 participants with brain tumors or epilepsy will have temporary electrodes placed during surgery, and 10 people with severe speech loss will…

This study follows 500 people with primary progressive aphasia, a condition that slowly damages the brain's language areas. Researchers will use brain scans and language tests to map how the disease progresses over time. The goal is to better understand the disease, not to test a…

This study looks at how memory, learning, and language differ in adults with aphasia (a language disorder from brain injury) compared to healthy adults and seniors. Researchers will test 600 participants using memory and language tasks. The goal is to better understand these cogn…

This study looks at how hearing sensitivity (hyperacusis) might help language skills in children and adults with Williams syndrome. Researchers will use EEG and NIRS brain scans along with questionnaires to compare participants with Williams syndrome, Down syndrome, and typical d…

This study uses advanced brain scans, including a special PET tracer called AV-1451, to track changes in the brains of 50 people with progressive apraxia of speech (a disorder that affects the ability to coordinate speech movements). Researchers at Mayo Clinic will compare these …

This study looks at how children with developmental language disorder (DLD) learn patterns in speech and grammar. Researchers want to see if a general difficulty with learning sequences links problems with sounds and sentence structure. The goal is to create better, earlier tests…

This study looks at how children who stutter perform on rhythm tasks compared to children who don't stutter. Researchers will test rhythm perception and production once a year for three years in 500 children. The goal is to understand how rhythm skills might be linked to brain ac…

This study gives aripiprazole, a drug that affects dopamine, to 40 adults who stutter to see how it changes brain activity during speech. Researchers use brain scans and audio recordings to measure how the brain processes sound before and during speaking. The goal is to better un…

This study looks at how children who stutter process speech sounds compared to children who do not stutter. Researchers will use hearing tests, brain wave recordings (EEG), and brain scans (fMRI) to measure brain activity. The goal is to understand the differences in speech proce…