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New brain scan study aims to unravel mysteries of speech disorder

NCT ID NCT01818661

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study uses advanced brain scans, including a special PET tracer called AV-1451, to track changes in the brains of 50 people with progressive apraxia of speech (a disorder that affects the ability to coordinate speech movements). Researchers at Mayo Clinic will compare these brain images with changes in speech, language, and thinking over time. The goal is to better understand how the disease progresses, which could improve diagnosis and monitoring in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AV-1451 (a radioactive tracer used in PET scans to detect tau protein in the brain)

What this could lead to

If successful, this study could help doctors better understand how progressive apraxia of speech affects the brain, potentially leading to earlier diagnosis or better monitoring of the disease.

What could go wrong

This is an observational imaging study, not a treatment trial. It is small (50 participants) and focused on understanding the disease, so it will not directly lead to a new therapy or cure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

aphasia Aphasia, Broca apraxia childhood apraxia of speech primary progressive aphasia progressive non-fluent aphasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APRAXIA OF SPEECH NON-FLUENT APHASIA PPA PRIMARY PROGRESSIVE APHASIA PRIMARY PROGRESSIVE NON-FLUENT APHASIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••