New brain scan study aims to unravel mysteries of speech disorder
NCT ID NCT01818661
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study uses advanced brain scans, including a special PET tracer called AV-1451, to track changes in the brains of 50 people with progressive apraxia of speech (a disorder that affects the ability to coordinate speech movements). Researchers at Mayo Clinic will compare these brain images with changes in speech, language, and thinking over time. The goal is to better understand how the disease progresses, which could improve diagnosis and monitoring in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AV-1451 (a radioactive tracer used in PET scans to detect tau protein in the brain)
- What this could lead to
- If successful, this study could help doctors better understand how progressive apraxia of speech affects the brain, potentially leading to earlier diagnosis or better monitoring of the disease.
- What could go wrong
- This is an observational imaging study, not a treatment trial. It is small (50 participants) and focused on understanding the disease, so it will not directly lead to a new therapy or cure.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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