Can retraining word meanings restore lost speech?

NCT ID NCT04957537

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exercises, then receive the semantic training in multiple sessions. Researchers measure improvements in naming accuracy and speed, and check if gains last a month later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
A structured speech therapy program focused on semantic training (analyzing word meanings) compared with a control phase of lexico-phonological exercises.
What this could lead to
If effective, this therapy could help people with semantic aphasia regain word-finding ability and slow language decline, improving daily communication.
What could go wrong
This is a very small early-stage study (15 people) without a control group, so results may not generalize. Benefits may be modest or not persist after therapy ends.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Toulouse

    RECRUITING

    Toulouse, France

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