New eye injection aims to tackle Diabetes-Related vision loss
NCT ID NCT06701721
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests an experimental drug called THN391, given as an injection into the eye, for people with diabetic macular edema (DME) — a condition where fluid builds up in the retina due to diabetes, causing vision loss. The trial involves 21 adults aged 18 to 80 with DME and vision loss. Researchers will check for side effects and measure changes in vision and retinal swelling over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- THN391
- What this could lead to
- If successful, THN391 could offer a new treatment option for diabetic macular edema, potentially improving vision and reducing retinal swelling.
- What could go wrong
- This is an early-phase trial with only 21 participants, so results may not apply broadly. The drug may cause side effects or fail to improve vision.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Eye Surgery Associates Pty Ltd
RECRUITINGMalvern, Victoria, 3144, Australia
-
Marsden Eye Specialists
RECRUITINGParramatta, New South Wales, 2150, Australia
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Princess Alexandria Hospital
RECRUITINGWoolloongabba, Queensland, 4102, Australia
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
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South Eastern Sydney Local Health District
RECRUITINGSydney, New South Wales, 2000, Australia
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Sunshine Eye Surgeons
RECRUITINGAlbans, Victoria, 3021, Australia
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Sydney West Retina
RECRUITINGWestmead, New South Wales, 2145, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI eye doctor: could software catch diabetic blindness sooner?
- Can a new eye injection preserve vision in south asians with diabetes?
- Can eye scans reveal hidden clues about diabetes damage?
- Could a biosimilar eye injection offer a new way to treat diabetic macular edema?
- Can a steroid implant boost the effect of standard eye injections for hard-to-treat diabetic macular edema?
- Eye injection aims to tame leading causes of blindness