DIABETIC RETINOPATHY

This early-stage trial tests an oral drug called MS-553 in 45 people with diabetic macular edema, a condition where diabetes causes fluid buildup in the eye's center, blurring vision. Participants take the drug daily for 8 weeks to check its safety and whether it reduces swelling…

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This study tests whether levosulpiride, a drug already used for other conditions, can safely improve vision and reduce retinal swelling in people with diabetic retinopathy and diabetic macular edema. About 120 adults aged 40-69 with mild to moderate eye damage will receive either…

This study compares having one laser treatment session versus several sessions for people with proliferative diabetic retinopathy, a serious eye condition that can lead to blindness. Researchers want to see which approach is safer and works better. About 40 adults with diabetes a…

This early-stage study tests a new dye called MB-102 for taking pictures of the back of the eye (ocular angiography). The goal is to see if it is safe and produces good images compared to the standard dye (fluorescein sodium). About 10 adults with healthy or diseased eyes will pa…

This study tests an AI software called iPredict-DR that analyzes eye photos to detect diabetic retinopathy early. About 922 adults with diabetes will get their eyes checked using a special camera, and the AI's results will be compared to expert graders. The goal is to see if the …

This study compares two ways of screening for diabetic eye disease: one using artificial intelligence (AI) to read eye photos, and the other using human eye doctors. About 922 adults with diabetes will take part. The goal is to see if AI can speed up referrals and treatment, pote…

This study tests a new, non-invasive eye imaging technique called hyperspectral imaging. It captures detailed images using many light wavelengths to find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in M…

This study tests a vision screening program in Danish general practice for people over 70 with at least one chronic condition. The goal is to see if the screening can catch vision problems early and refer patients to eye specialists. About 460 participants will be recruited, and …

This study tests whether fenofibrate, a drug already used for high cholesterol, can stop diabetic retinopathy from worsening in people with mild to moderate eye damage. About 560 adults with diabetes will take either fenofibrate or a placebo for up to 6 years. The goal is to see …

This study looks at whether taking melatonin can improve sleep and daily body rhythms in people with diabetic retinopathy, an eye problem caused by diabetes. Researchers will track sleep patterns and hormone levels in 42 adults aged 40-65. The goal is to see if a simple supplemen…

This study looks at a protein called sCD160 in the eye fluids and blood of people with diabetic retinopathy or retinal vein occlusion. Researchers want to see if higher levels of this protein are linked to more severe eye damage. The goal is to better understand these vision-thre…

This study follows 100 adults with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Over two years, researchers will use advanced eye scans to track tiny changes in blood vessels and retinal layers. The goal is to find earl…

This study looks at whether activating a protein called LXR, which controls cholesterol, can prevent diabetic retinopathy—a common eye complication of diabetes. Researchers will test blood cells from up to 104 people with and without diabetes to see how LXR activation affects cel…

This study looks at how to better detect and manage diabetic retinopathy, an eye problem caused by type 2 diabetes. Researchers will use eye images, clinical data, and blood tests to create an early warning system and tailor treatment based on when diabetes started and other heal…

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to create a research database to help scientists understand why some people get eye diseases and oth…

This study aims to see if short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get regular eye exams. Researchers will survey about 1,500 people and hold small group discussions to measure changes in eye health knowledge and trust i…

This study tests a new imaging technology that gives surgeons a live, 3D view inside the eye during surgery. It includes up to 262 participants, including healthy volunteers and patients with conditions like macular holes, retinal detachment, or cataracts. The goal is to see if t…

This study explores whether special stem cells made from a person's own blood can help repair damaged blood vessels in the eye caused by diabetic retinopathy. Researchers will take blood from 20 people with diabetes and healthy volunteers to create these stem cells in a lab. The …

This observational study will follow about 1,000 people with type 2 diabetes, aged 35 to 90, for one year. Researchers want to see if changes in the eye's blood vessels and tissues can predict which patients will develop more severe diabetic retinopathy or have heart problems lik…

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the retina. Researchers will follow about 1,050 people with retinal diseases (like diabetic retinopathy) and healthy volunteers over time. The goal is to find better ways to detect …

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…