DIABETIC RETINOPATHY

This study tests whether levosulpiride, a drug already used for other conditions, can safely improve vision and reduce retinal swelling in people with diabetic retinopathy and diabetic macular edema. About 120 adults aged 40-69 with mild to moderate eye damage will receive either…

This early-stage trial tests an oral drug called MS-553 in 45 people with diabetic macular edema, a condition where fluid builds up in the eye's center, blurring vision. Participants take the drug daily for 8 weeks to see if it is safe and can reduce swelling or improve eyesight.…

This study compares having one laser treatment session versus several sessions for people with proliferative diabetic retinopathy, a serious eye condition that can lead to blindness. Researchers want to see which approach is safer and works better. About 40 adults with diabetes a…

This study looks at whether opening blocked leg arteries within 48 hours helps heal foot ulcers in people with type 2 diabetes. About 200 adults with diabetic foot ulcers will be randomly assigned to early or standard treatment. Researchers will track wound healing with a 3D came…

This study tests an AI software called iPredict-DR that analyzes eye photos to detect diabetic retinopathy, a leading cause of blindness, at an early stage. About 922 adults with diabetes will have their eyes photographed in primary care clinics, and the AI's accuracy will be com…

This early study tests a new dye called MB-102 for taking pictures of the blood vessels in the back of the eye. The goal is to see if it is safe and provides good images compared to the standard dye used today. About 10 adults with healthy eyes or conditions like diabetic retinop…

This study compares two ways of screening for diabetic eye disease: one using artificial intelligence (AI) to read eye photos, and the other using human eye doctors. About 922 adults with diabetes will take part. The goal is to see if AI can speed up referrals and treatment, pote…

This study tests a new, non-invasive eye imaging technique called hyperspectral imaging. It captures detailed images using many light wavelengths to find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in M…

This study tests a vision screening program in Danish general practice for people over 70 with at least one chronic condition. The goal is to see if the screening can catch vision problems early and refer patients to eye specialists. About 460 participants will be recruited, and …

This study will test a new way to detect and manage diabetic retinopathy, an eye problem caused by type 2 diabetes. About 2,920 adults will have their eyes checked and give blood samples to help create better models for early warning and treatment. The goal is to prevent vision l…

This study tests whether fenofibrate, a drug already used for high cholesterol, can stop diabetic retinopathy from getting worse. About 560 adults with mild to moderate diabetic eye disease will take either fenofibrate or a placebo for up to 6 years. The goal is to see if the dru…

This study is testing whether taking melatonin supplements can improve sleep patterns and daily body rhythms in people with diabetic retinopathy, an eye complication of diabetes. Researchers will monitor sleep, melatonin, and cortisol levels in 42 adults aged 40-65 with type 2 di…

This study tests whether short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get yearly eye exams. Researchers will survey 1,500 people and hold small group discussions. The goal is to see if these videos improve eye health knowled…

This study explores whether special stem cells made from a person's own blood can help repair damaged blood vessels in the eye caused by diabetic retinopathy. Researchers will take blood from 20 people with diabetes and healthy volunteers to create these stem cells in a lab. The …

This study looks at whether activating a protein called LXR can help prevent diabetic retinopathy, a common eye problem in people with diabetes. Researchers will test blood samples from 104 adults with and without diabetes to see how LXR affects cholesterol and the function of ce…

This observational study will follow about 1,000 people with type 2 diabetes, aged 35 to 90, for one year. Researchers want to see if changes in the eye's blood vessels and tissues can predict which patients will develop more severe diabetic retinopathy or have heart problems lik…

This study tests a new microscope that shows live 3D images inside the eye during surgery. It includes up to 262 people with various eye conditions like retinal detachment, cataracts, or macular holes, as well as healthy volunteers. The goal is to see if this technology helps sur…

This study collects blood, tissue, and health information from 650 people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to build a database and biobank for future research, not to provide treatment. Participants will…

This study follows 100 people with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Researchers will use advanced eye scans and tests over two years to track small changes in the retina. The goal is to find early warning si…

This study looks at a protein called sCD160 in the eye fluids and blood of people with diabetic retinopathy or retinal vein occlusion. Researchers want to see if higher levels of this protein are linked to these eye conditions. The study involves 120 adults and uses blood and eye…

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the retina. Researchers will follow about 1,050 people with retinal diseases (like diabetic retinopathy) and healthy volunteers over time. The goal is to find better ways to detect …

This study looks at different ways to help people with age-related macular degeneration, diabetic retinopathy, or glaucoma get to their eye hospital appointment after a screening. About 3,000 participants will be split into three groups: some get text reminders, some get calls fr…