DIABETIC RETINOPATHY

This study tests whether ketorolac, an anti-inflammatory eye drop, can reduce inflammation in the eyes of people with diabetic retinopathy and slow the disease. About 164 adults with type 2 diabetes will use either the active drop or a placebo for up to 3 years. Researchers will …

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested a new eye implant called PER-001 in 27 people with diabetic retinopathy, a diabetes complication that can damage vision. The implant is placed inside the eye and releases medication over time. The main goal was to check safety and how well people tolerate it, lo…

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center…

This study tested whether levodopa, a drug used for Parkinson's disease, can help people with diabetes who have early signs of eye damage (diabetic retinopathy). The goal was to find the best dose and understand how it works to improve the retina's electrical signals. 230 adults …

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This small Phase 2 study tested INV-102 eye drops in 19 people with diabetic macular edema, a swelling in the back of the eye caused by diabetes. Participants used the drops daily for 8 to 12 weeks. The goal was to see if the drops could improve retinal health and reduce swelling…

This study tested a herbal extract called Nuvastatic in 100 adults with type 2 diabetes who have early-stage diabetic retinopathy (eye damage). The goal was to see if it can safely slow the disease and improve vision. Participants received either the extract or a placebo, and res…

This study looked at whether taking omega-3 supplements for 6 months can improve blood flow in the eyes of people with mild to moderate diabetic retinopathy, a common diabetes complication. Researchers measured tiny blood vessels in the retina using a special camera. The goal was…

This study tested whether aflibercept injections into the eye can improve areas of poor blood flow in the retina of people with diabetic retinopathy. 38 adults with nonproliferative diabetic retinopathy received the treatment. The goal was to see if the drug could reduce the risk…

This study tested an artificial intelligence (AI) algorithm to detect diabetic retinopathy and glaucoma from eye photos. Researchers compared the AI's accuracy to that of family doctors and retina specialists. The goal was to see if AI could be a reliable screening tool in primar…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tested whether an AI tool can help eye doctors diagnose four common retinal diseases (diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and glaucoma) more accurately and quickly. Ten doctors from five hospitals read fundus images both with…

This study tested a software called OPTDR01 that automatically checks retinal images for signs of diabetic retinopathy, a leading cause of vision loss. Researchers enrolled 300 adults with diabetes to see if the tool is easy to use and practical in a clinic setting. The goal is t…

This study tested a new device called CRYSTALSIGHT that uses eye-tracking and artificial intelligence to monitor macular diseases like age-related macular degeneration and diabetic retinopathy. Twenty participants used the device at home to see if it could accurately track eye mo…

This study tested a new imaging device called OCT angiography (OCTA) that takes 3D pictures of blood vessels in the back of the eye without needing dye injections. Researchers compared OCTA images to standard dye-based imaging in 88 people with retinal blood vessel problems or no…

This study tested a nursing intervention designed to help patients relax and feel more comfortable during diabetic retinal laser surgery. 136 adults received either standard care or extra support including guided breathing, clear communication, and reassurance. The goal was to se…

This study reviews published research on artificial intelligence models that analyze retinal images to predict how well patients with diabetic macular edema will respond to treatments like anti-VEGF injections or laser therapy. By evaluating the accuracy of these AI tools, the re…

This study tested whether doctors could safely and correctly use a new prefilled syringe (SCD411) for eye injections. It included 33 adults with wet age-related macular degeneration, retinal vein occlusion, diabetic macular edema, or diabetic retinopathy. The main goal was to see…

This study looked at whether monitoring moderate diabetic retinopathy (an eye condition caused by diabetes) through tele-expertise (remote specialist review) works as well as the usual in-person eye doctor visits. Researchers followed 97 patients with diabetes and moderate retino…

This study looked at 60 adults with type 2 diabetes and early diabetic eye disease. Researchers used a special eye scan (OCTA) to measure blood flow in the retina. The goal was to find which scan details best predict if the disease will get worse and threaten sight. No treatment …

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study measured three substances in the blood (endocan, alarin, and galanin-like peptide) in people with and without diabetic retinopathy, an eye complication of diabetes. Researchers compared these levels across different stages of the disease and looked at how they relate t…

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This study looked at whether specific features on eye imaging scans can predict how well a person with diabetic macular edema will respond to treatment. Researchers analyzed images from 32 participants to find patterns linked to better or worse outcomes. The goal is to help docto…