New pill could replace eye injections for Diabetes-Related vision loss
NCT ID NCT04187443
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests an oral drug called MS-553 in 45 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. Participants take the drug daily for 8 weeks. The main goal is to check safety, but researchers will also measure changes in retinal swelling and vision. If safe, larger studies could follow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MS-553 (oral drug)
- What this could lead to
- If successful, this could point toward a new oral treatment option for diabetic macular edema, potentially reducing the need for eye injections.
- What could go wrong
- This is an early Phase 1 trial with only 45 people, focused on safety. It is too small and early to know if the drug will work or be safe long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shanghai General Hospital
RECRUITINGShanghai, 200080, China
-
The Second Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, China
-
West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI eye doctor: could software catch diabetic blindness sooner?
- Can a new eye injection preserve vision in south asians with diabetes?
- Can eye scans reveal hidden clues about diabetes damage?
- Could a biosimilar eye injection offer a new way to treat diabetic macular edema?
- Can a steroid implant boost the effect of standard eye injections for hard-to-treat diabetic macular edema?
- Eye injection aims to tame leading causes of blindness