New hope for AF patients: device may replace blood thinners after brain bleed
NCT ID NCT04298723
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to either the device procedure or continued blood thinner medication. The goal is to see which approach better prevents strokes, heart-related death, and serious bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Watchman or Watchman FLX left atrial appendage closure device
What this could lead to
If successful, this could offer a safer alternative to long-term blood thinners for AF patients who have already had a brain bleed, reducing both stroke and bleeding risks.
What could go wrong
This is a mid-sized trial (530 participants) and the device procedure itself carries risks like bleeding, infection, or device complications. Results may not apply to all AF patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asklepios Klinik Altona
RECRUITINGHamburg, Free and Hanseatic City of Hamburg, 22763, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Asklepios Klinik Nord Heidberg
RECRUITINGHamburg, Free and Hanseatic City of Hamburg, 22417, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Asklepios Klinik Wandsbek
RECRUITINGHamburg, Free and Hanseatic City of Hamburg, 22043, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cardiologicum Hamburg
RECRUITINGHamburg, Free and Hanseatic City of Hamburg, 22041, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Charité - Universitätsmedizin Berlin (CBF)
RECRUITINGBerlin, State of Berlin, 12203, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Charité - Universitätsmedizin Berlin (CVK
ACTIVE_NOT_RECRUITINGBerlin, State of Berlin, 13353, Germany
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Dresden Heart Center
RECRUITINGDresden, Saxony, 01307, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Evangelisches Klinikum Bethel
RECRUITINGBielefeld, North Rhine-Westphalia, 33617, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Górnośląskim Centrum Medycznym
RECRUITINGKatowice, Silesian Voivodeship, 40-635, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Heart Center Leipzig
RECRUITINGLeipzig, Saxony, 04289, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Heinrich-Braun-Klinikum (HBK)
RECRUITINGZwickau, Saxony, 08060, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Helios Klinikum Erfurt
RECRUITINGErfurt, Thuringia, 99089, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Helios Klinikum Pirna
RECRUITINGPirna, Saxony, 01796, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Herz-Kreislauf-Zentrum
ACTIVE_NOT_RECRUITINGRotenburg an der Fulda, Hesse, 44137, Germany
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Katholisches Klinikum Koblenz • Montabaur
RECRUITINGKoblenz, Rhineland-Palatinate, 56073, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum Chemnitz
RECRUITINGChemnitz, Saxony, 09113, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum Dortmund
ACTIVE_NOT_RECRUITINGDortmund, North Rhine-Westphalia, 44137, Germany
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Klinikum Ingolstadt
RECRUITINGIngolstadt, Bavaria, 85049, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum St. Georg
RECRUITINGLeipzig, Saxony, 04129, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Knappschaft Kliniken
RECRUITINGDortmund, North Rhine-Westphalia, 44309, Germany
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Polsko-Amerykańskie Kliniki Serca
NOT_YET_RECRUITINGBielsko-Biala, Silesian Voivodeship, 43-316, Poland
Contact Email: •••••@•••••
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REGIOMED Klinikum Coburg
RECRUITINGCoburg, Bavaria, 96450, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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RHÖN-KLINIKUM Campus Bad Neustadt
ACTIVE_NOT_RECRUITINGBad Neustadt an der Saale, Bavaria, 97616, Germany
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RoMed Klinikum
ACTIVE_NOT_RECRUITINGRosenheim, Bavaria, 83022, Germany
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Therapiezentrum Burgau
ACTIVE_NOT_RECRUITINGBurgau, Bavaria, 89331, Germany
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University Hospital Jena
RECRUITINGJena, Thuringia, 07747, Germany
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Leipzig
RECRUITINGLeipzig, Saxony, 04103, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Magdeburg
RECRUITINGMagdeburg, Saxony-Anhalt, 68167, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Mannheim
RECRUITINGMannheim, Baden-Wurttemberg, 68167, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Erlangen
RECRUITINGErlangen, Bavaria, 91054, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Schleswig-Holstein (UKSH)
RECRUITINGLübeck, Schleswig-Holstein, 23538, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Uniwersytecki Szpital Kliniczny w Poznaniu
NOT_YET_RECRUITINGPoznan, Greater Poland Voivodeship, 61-848, Poland
Contact Email: •••••@•••••
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Westpfalz-Klinikum
RECRUITINGKaiserslautern, Rhineland-Palatinate, 67655, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••