INTRACRANIAL HEMORRHAGES

This study tests whether clot-busting drugs (alteplase or tenecteplase) are safe and effective for stroke patients who have taken a blood thinner (FXa inhibitor) in the last 48 hours. Current guidelines avoid this treatment due to bleeding concerns, but new evidence suggests it m…

This study tests whether closing a small pouch in the heart (the left atrial appendage) with a device is safer and as effective as long-term blood thinners for people with atrial fibrillation who have already had a brain bleed. About 530 participants will be randomly assigned to …

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

This study will follow 5,000 people who receive newer endovascular devices (like coils, stents, or flow diverters) to treat a brain aneurysm. Researchers want to see how often the aneurysm comes back and what factors, such as smoking, might play a role. The goal is to improve saf…

This study is testing a new monitor that tracks brain pressure over time in patients with serious brain injuries like trauma or bleeding. Researchers want to see if the pressure measurements can predict who will survive or recover well. The study will enroll 250 adults and follow…