Could stroke patients on blood thinners finally get clot-busting treatment?
NCT ID NCT06878066
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether clot-busting drugs (alteplase or tenecteplase) are safe and effective for stroke patients who have taken a blood thinner (FXa inhibitor) in the last 48 hours. Current guidelines avoid this treatment due to bleeding concerns, but new evidence suggests it may be safe. The trial will compare 300 patients who receive the clot-buster with those who get standard care, measuring recovery and bleeding risks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Alteplase or Tenecteplase (clot-busting drugs)
What this could lead to
If successful, this could change stroke treatment guidelines so that more patients on blood thinners can receive life-saving clot-busting therapy without delay.
What could go wrong
This is a phase 3 trial, but results may not apply to all patients. There is a risk of brain bleeding, and the study does not require a blood test to measure drug levels before treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dept of Medicine, Haraldsplass deaconal Hospital
RECRUITINGBergen, 5009, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Medicine, Helse More and Romsdal Health Trust, Aalesund Hospital
RECRUITINGÅlesund, 6017, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Neurology, Drammen Hospital Trust
RECRUITINGDrammen, 3004, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Neurology, Hospital of Southern Norway, SSHF
RECRUITINGKristiansand, 4615, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Neurology, Innlandet Hospital Trust, Lillehammer
RECRUITINGLillehammer, 2609, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Neurology, Ostfold Hospital Trust, Kalnes
RECRUITINGGrålum, 1714, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Neurology, Stavanger University Hospital
RECRUITINGStavanger, 4011, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept of Neurology, Vesfold Hospital Trust, Tonsberg
RECRUITINGTønsberg, 3103, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept. Of Medicine, St.Olav Hospital, Trondheim
RECRUITINGTrondheim, 7030, Norway
Contact Email: •••••@•••••
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Dept. Of Neurology, Haukeland University Hopsital
RECRUITINGBergen, 5009, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept. of Medicine, Baerum Hospital
RECRUITINGBærum, Gjettum, 1346, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dept. of Neurology, Oslo University Hospital
RECRUITINGOslo, 0450, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Dept. of Neurology, Tromso University Hospital
RECRUITINGTromsø, 9019, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••