Glowing probe aims to improve brain tumor diagnosis

NCT ID NCT07286903

Recruiting now Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new fiber optic probe that combines three technologies (fluorescence, Raman spectroscopy, and ultrasound) to help doctors see tumor tissue and blood vessels during brain biopsies. The probe will be tested on brain tumor tissue removed from 20 patients with high-grade glioma. The goal is to see if the probe can accurately identify tumor margins and blood vessels, which could make biopsies safer and more likely to get a good sample.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 5-ALA (a drug that makes tumor cells glow)
What this could lead to: If successful, this probe could make brain tumor biopsies safer and more accurate, reducing the need for repeat procedures.
What could go wrong: This is a very early, small (20 people) ex-vivo study testing the probe on removed tissue, not yet in live patients. The technology may not work as well in real-time surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE GLIOMA HIGH GRADE GLIOMA (III OR IV)

Contacts and locations

Locations

Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, Italy

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